{"id":"W2961174880","doi":"10.1080/15548627.2019.1705007","title":"Podocytes maintain high basal levels of autophagy independent of mtor signaling","year":2019,"lang":"en","type":"article","venue":"Autophagy","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bundesministerium für Bildung und Forschung; National Natural Science Foundation of China; Rijksuniversiteit Groningen; Horizon 2020 Framework Programme; Deutsche Forschungsgemeinschaft; European Foundation for the Study of Diabetes; Ministère de l'Économie, de la Science et de l'Innovation - Québec; European Federation of Pharmaceutical Industries and Associations; Uehara Memorial Foundation; European Commission; Alexander von Humboldt-Stiftung","keywords":"Autophagy; PI3K/AKT/mTOR pathway; Biology; Cell biology; Podocin; Podocyte; Protein kinase A; AMPK; ULK1; ATG16L1; BAG3; RPTOR; Kinase; Signal transduction; Endocrinology; Kidney; Biochemistry; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002581692,0.0001936306,0.0006152909,0.000182751,0.00002412953,0.000008859857,0.0001799584,0.0001200491,0.002505262],"category_scores_gemma":[0.0001506321,0.0001614673,0.000238662,0.0002138703,0.00009029255,0.00009316858,0.0001219628,0.0001524052,0.0001038287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005243409,"about_ca_system_score_gemma":0.0002147844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001981556,"about_ca_topic_score_gemma":0.000001626203,"domain_scores_codex":[0.9982958,0.00006285898,0.0005382956,0.0002882425,0.0005163858,0.00029843],"domain_scores_gemma":[0.9988176,0.0001426279,0.0002447791,0.0004714367,0.0001714472,0.0001520973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009935836,0.0007845836,0.02714383,0.002273039,0.0005154198,0.0002689863,0.0005643992,0.0004207116,0.9242404,0.02776589,0.0003300325,0.01469909],"study_design_scores_gemma":[0.002086095,0.0007812825,0.4415554,0.0003575998,0.0001343493,0.00002069436,0.0002195454,0.0004421831,0.5508529,0.003161074,0.0002166548,0.0001721629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961283,0.001717815,0.0001366641,0.0001568087,0.0002810926,0.0003542876,0.00010293,0.00004281633,0.001079319],"genre_scores_gemma":[0.9971436,0.00004445108,0.001006114,0.0002293887,0.0001088799,0.000007862353,0.00001970519,0.00003040442,0.001409595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4144116,"threshold_uncertainty_score":0.9984066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277721431149017,"score_gpt":0.2584287390921109,"score_spread":0.2456515247806207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}