{"id":"W2961502705","doi":"10.1097/qad.0000000000002256","title":"Drug interactions are not always predictable","year":2019,"lang":"en","type":"letter","venue":"AIDS","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; McGill University Health Centre; Toronto General Hospital","funders":"","keywords":"Efavirenz; Dolutegravir; Valproic Acid; Drug interaction; Pharmacology; Anticonvulsant; Pharmacokinetics; CYP3A4; Medicine; Lamivudine; Epilepsy; Chemistry; Internal medicine; Human immunodeficiency virus (HIV); Cytochrome P450; Virology; Viral load; Metabolism; Virus; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002230446,0.0007056328,0.001042204,0.0007609008,0.001000577,0.001921821,0.000628197,0.002054186,0.04569238],"category_scores_gemma":[0.01844779,0.0002634457,0.0009343129,0.0008593914,0.0009587274,0.002419446,0.001362293,0.003467318,0.02200072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001051258,"about_ca_system_score_gemma":0.001178733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001315026,"about_ca_topic_score_gemma":0.002143098,"domain_scores_codex":[0.9962739,0.001367245,0.0004381214,0.0004939412,0.001174794,0.0002519759],"domain_scores_gemma":[0.9902125,0.003784841,0.002315779,0.0009408106,0.002096752,0.0006492438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009119223,0.0004599736,0.02730051,0.001941819,0.000649304,0.01592036,0.0004065349,0.0008510125,0.003231075,0.02076133,0.2099988,0.7175673],"study_design_scores_gemma":[0.0002297027,0.0005453064,0.01586353,0.00158403,0.0002725233,0.04229901,0.0003309383,0.0009577328,0.001671192,0.02354853,0.9126232,0.00007415986],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"commentary","genre_scores_codex":[0.08277356,0.2259346,0.05089623,0.1228333,0.008920241,0.00171979,0.005717042,0.003872187,0.4973331],"genre_scores_gemma":[0.6147907,0.08731766,0.02202046,0.08022565,0.008493249,0.000923038,0.003025427,0.0008860222,0.1823179],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.04569238,"threshold_uncertainty_score":0.1528562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.036019684189598,"score_gpt":0.312461815626816,"score_spread":0.276442131437218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}