{"id":"W2961502705","doi":"10.1097/qad.0000000000002256","title":"Drug interactions are not always predictable","year":2019,"lang":"en","type":"letter","venue":"AIDS","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; McGill University Health Centre; Toronto General Hospital","funders":"","keywords":"Efavirenz; Dolutegravir; Valproic Acid; Drug interaction; Pharmacology; Anticonvulsant; Pharmacokinetics; CYP3A4; Medicine; Lamivudine; Epilepsy; Chemistry; Internal medicine; Human immunodeficiency virus (HIV); Cytochrome P450; Virology; Viral load; Metabolism; Virus; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001091156,0.0002704811,0.0006534146,0.0001165429,0.0000957759,0.00002218139,0.0001305375,0.0002131458,0.001076514],"category_scores_gemma":[0.0001772065,0.0001906034,0.0002292536,0.0001167962,0.0000729725,0.00006641322,0.0001396351,0.002053674,0.0009766684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001052515,"about_ca_system_score_gemma":0.00004333793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005288336,"about_ca_topic_score_gemma":0.000002699584,"domain_scores_codex":[0.9986825,0.00006498407,0.0002140183,0.0003700758,0.0003072441,0.0003611742],"domain_scores_gemma":[0.9989069,0.0005139387,0.0001288682,0.0003046256,0.00008920323,0.00005646437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003659025,0.00007247966,0.001718169,0.00033975,0.0003676305,0.000390118,0.00005811566,0.000001148876,0.0005777208,0.000003085776,0.9959483,0.0004869528],"study_design_scores_gemma":[0.0006789551,0.0002292749,0.002116104,0.0002904392,0.0003547929,0.00003487639,0.0000302828,0.00005177726,0.0009617964,0.00002269044,0.9950381,0.0001909264],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01281578,0.0004166902,0.00003114122,0.9368312,0.002749663,0.0008271081,0.000189025,0.000228953,0.04591039],"genre_scores_gemma":[0.07971474,0.0001121374,0.00007959989,0.8088638,0.005284692,0.00007328075,0.0001439066,0.00003675845,0.1056911],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1279674,"threshold_uncertainty_score":0.9998366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.036019684189598,"score_gpt":0.312461815626816,"score_spread":0.276442131437218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}