{"id":"W2961547340","doi":"10.1007/s40259-019-00366-1","title":"Factors Influencing Drug Disposition of Monoclonal Antibodies in Inflammatory Bowel Disease: Implications for Personalized Medicine","year":2019,"lang":"en","type":"review","venue":"BioDrugs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"Medicine; Inflammatory bowel disease; Ulcerative colitis; Drug; Therapeutic drug monitoring; Personalized medicine; Monoclonal antibody; Pharmacodynamics; Dosing; Pharmacokinetics; Crohn's disease; Precision medicine; Efficacy; Disease; Pharmacotherapy; Pharmacology; Immunology; Intensive care medicine; Internal medicine; Bioinformatics; Antibody; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007754379,0.0005808015,0.001611311,0.001258645,0.0001166102,0.001013437,0.0005593006,0.0009280935,0.002269437],"category_scores_gemma":[0.001601352,0.0001836416,0.0008537816,0.001573158,0.0003599809,0.0008082103,0.0004050761,0.001256309,0.0005372436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004702292,"about_ca_system_score_gemma":0.0009233843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0012678,"about_ca_topic_score_gemma":0.002230101,"domain_scores_codex":[0.9997662,0.00006239453,0.00004193899,0.00004952515,0.00006241733,0.00001749478],"domain_scores_gemma":[0.9990008,0.0006916857,0.0001552953,0.00001438862,0.0001126456,0.00002513504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002450831,0.0001018106,0.001453878,0.02093496,0.0005278279,0.0001669297,0.00003360222,0.0004149133,0.0008800462,0.001897935,0.01087227,0.9624707],"study_design_scores_gemma":[0.0002029931,0.0006634135,0.01279156,0.02115396,0.003428175,0.002938858,0.0002051428,0.0006631696,0.001475084,0.007016886,0.9493522,0.0001084928],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001517543,0.9993773,0.00006024288,0.0001622757,0.00005097056,0.000001526882,0.00001481783,0.000001836324,0.0001792524],"genre_scores_gemma":[0.001063738,0.9983482,0.0001329486,0.0001757936,0.0001310372,0.000003430066,0.00002083249,5.410367e-7,0.0001234108],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002269437,"threshold_uncertainty_score":0.007592082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1079329269223195,"score_gpt":0.4040673753673309,"score_spread":0.2961344484450115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}