{"id":"W2961677697","doi":"10.1101/701656","title":"The PAX3 and 7 homeodomains have evolved unique determinants that influence DNA-binding, structure and communication with the paired domain","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Homeobox; Biology; DNA; Genetics; Hox gene; Transcription factor; Binding site; DNA-binding domain; PAX3; Gene; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023786,0.0001552952,0.0001182242,0.0001019909,0.0001083103,0.0001606639,0.0001582129,0.0001941282,0.0009479003],"category_scores_gemma":[0.0001159723,0.0001083044,0.0001892434,0.00008895318,0.0002173292,0.0001941913,0.0002611395,0.000315027,0.0002607815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001746281,"about_ca_system_score_gemma":0.0001046986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002251058,"about_ca_topic_score_gemma":0.0004191312,"domain_scores_codex":[0.9999222,0.00001201381,0.000004069879,0.00001589705,0.0000258398,0.00001995329],"domain_scores_gemma":[0.9999341,0.0000153241,0.00001902081,0.000007452619,0.000006529092,0.00001754222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002444169,0.000003679242,0.0003524873,0.00000870471,0.000002215487,0.00002465425,0.000005517247,0.00003199395,0.9989251,0.0001438719,0.000004853669,0.0004724025],"study_design_scores_gemma":[0.000007670613,0.0001305442,0.01562542,0.000004276421,0.00001291159,0.0005689071,0.00005064532,0.001415224,0.9802585,0.0002073569,0.001712905,0.00000563899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977483,0.000229487,0.001539056,0.00001535061,0.000004289647,0.000004422317,0.00005384727,0.00001162462,0.0003936972],"genre_scores_gemma":[0.9977253,0.00009211191,0.001371243,0.00001786482,0.000003272666,0.000006402053,0.0001665266,0.000007318008,0.0006098968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009479003,"threshold_uncertainty_score":0.003171027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005724353221630559,"score_gpt":0.2257283904290499,"score_spread":0.2200040372074193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}