{"id":"W2961941479","doi":"10.3791/59920","title":"Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16","year":2019,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Ministry of Science and Technology, Taiwan; University of Texas at Austin","keywords":"Coxsackievirus; Antiviral drug; Viral entry; Virology; Virus; Capsid; Biology; Docking (animal); Viral envelope; Computational biology; Viral replication; Enterovirus; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004465213,0.0008562738,0.0006570362,0.0005720006,0.0003904503,0.0004208845,0.000460817,0.0003428406,0.001561506],"category_scores_gemma":[0.0003807024,0.0003047496,0.0005698943,0.0004973872,0.0003906635,0.0003768311,0.0003176896,0.0008275246,0.0003562321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005425279,"about_ca_system_score_gemma":0.0004232837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001297794,"about_ca_topic_score_gemma":0.002294359,"domain_scores_codex":[0.9996495,0.00008729804,0.00003249257,0.0000454421,0.0001283209,0.00005684667],"domain_scores_gemma":[0.9997481,0.00007855721,0.00006237597,0.00003383346,0.00004031972,0.00003698817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001868668,0.0001014163,0.000224394,0.00004371415,0.00001461455,0.0000206947,0.00001291877,0.001142211,0.9962262,0.0001788766,0.00002153169,0.001826583],"study_design_scores_gemma":[0.00003368795,0.0007739809,0.00135849,0.000004842908,0.00001156979,0.00006772573,0.00001534861,0.004522268,0.9927036,0.00006654559,0.0004273249,0.0000146736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9700446,0.00138889,0.0256061,0.00008381907,0.00002775105,0.0002269515,0.0005660076,0.0001488363,0.001907097],"genre_scores_gemma":[0.9536133,0.001591364,0.04075412,0.00003390259,0.00000621519,0.0002406208,0.00105985,0.0000444702,0.002656156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001561506,"threshold_uncertainty_score":0.005223691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0444921759844142,"score_gpt":0.4409643068281399,"score_spread":0.3964721308437257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}