{"id":"W2961965854","doi":"10.1101/702571","title":"Modulation of Actin network and Tau phosphorylation by HDAC6 ZnF UBP domain","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; National Chemical Laboratory; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Cell biology; HDAC6; Cytoskeleton; Microtubule; Phosphorylation; Tau protein; Immunocytochemistry; Microtubule-associated protein; Neurofilament; Biology; Actin; Neurite; Lamellipodium; Chemistry; Alzheimer's disease; Cell; Pathology; Biochemistry; Immunology; Medicine; Histone; Disease; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006059405,0.0001907948,0.00009331289,0.0001005259,0.0001290834,0.0001436032,0.0001379741,0.000129044,0.002210075],"category_scores_gemma":[0.00004213267,0.00006035847,0.0001318062,0.00008598237,0.0001233116,0.00008148684,0.00008085052,0.0002342488,0.0004647038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002042898,"about_ca_system_score_gemma":0.00006587639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006899165,"about_ca_topic_score_gemma":0.0008543367,"domain_scores_codex":[0.9999621,0.000005212418,0.000002416936,0.000008120175,0.0000093486,0.00001292842],"domain_scores_gemma":[0.9999816,0.00000285656,0.00000484396,0.000002455136,0.000002624091,0.000005504993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001703233,0.0000210286,0.0001645362,0.00002759459,0.000003280785,0.00003162651,0.000004633109,0.00002833223,0.9984329,0.00005994428,0.00007070002,0.0009850424],"study_design_scores_gemma":[0.00001457573,0.00006128558,0.003914973,0.000002303125,0.000005061478,0.0000724459,0.00000834495,0.0004296199,0.9939032,0.00002772,0.001559255,0.000001151916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922941,0.001975594,0.001716412,0.0001538407,0.00006217817,0.0000197535,0.0008025628,0.00004799353,0.002927604],"genre_scores_gemma":[0.9919871,0.001004148,0.001343182,0.00004177155,0.00001724811,0.00001675163,0.0007970683,0.00001827897,0.00477438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002210075,"threshold_uncertainty_score":0.007393479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141543676855442,"score_gpt":0.250882806163687,"score_spread":0.2367284384781428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}