{"id":"W2962303618","doi":"10.1007/s11307-019-01397-4","title":"Transcranial Photoacoustic Detection of Blood-Brain Barrier Disruption Following Focused Ultrasound-Mediated Nanoparticle Delivery","year":2019,"lang":"en","type":"article","venue":"Molecular Imaging and Biology","topic":"Photoacoustic and Ultrasonic Imaging","field":"Engineering","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of Biomedical Imaging and Bioengineering; Terry Fox Research Institute; Canada Research Chairs","keywords":"Ex vivo; In vivo; Transcranial Doppler; Ultrasound; Photoacoustic imaging in biomedicine; Indocyanine green; Biomedical engineering; Materials science; Evans Blue; Fluorophore; Blood–brain barrier; Fluorescence; Chemistry; Medicine; Pathology; Radiology; Central nervous system; Biology; Optics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000263461,0.0003696115,0.0001858329,0.00021537,0.0002455602,0.0003664898,0.0005491253,0.0007691009,0.001773975],"category_scores_gemma":[0.0005020428,0.0001817876,0.0001934362,0.0001703124,0.0005123109,0.000551335,0.000240911,0.0009866829,0.0003583978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003950553,"about_ca_system_score_gemma":0.0003168206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001514914,"about_ca_topic_score_gemma":0.002169512,"domain_scores_codex":[0.9998711,0.00002221366,0.000003490322,0.00003317907,0.00003105862,0.00003892334],"domain_scores_gemma":[0.9998049,0.00009206751,0.00004171234,0.00001431626,0.00002387898,0.00002322303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002351891,0.00002653643,0.00004905772,0.00004349565,0.000004813862,0.0001045187,0.00004571069,0.00003380584,0.9971327,0.0001321093,0.0001170195,0.002075024],"study_design_scores_gemma":[0.00003225418,0.0004430941,0.002614746,0.000009716155,0.00002585115,0.0002976626,0.00006390745,0.00128378,0.9943615,0.0001180493,0.0007389124,0.00001052141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.956427,0.005476329,0.03067216,0.0005826193,0.0002540279,0.0001285074,0.0001953728,0.0002815328,0.005982509],"genre_scores_gemma":[0.9869894,0.001605802,0.00719115,0.0002960136,0.00006691653,0.0001154284,0.0001083951,0.00002571103,0.003601203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001773975,"threshold_uncertainty_score":0.005934536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003545321667933523,"score_gpt":0.1951966858195587,"score_spread":0.1916513641516251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}