{"id":"W2962367258","doi":"10.1016/j.antiviral.2019.104561","title":"The Val430Ile neuraminidase (NA) substitution, identified in influenza B virus isolates, impacts the catalytic 116Arg residue causing reduced susceptibility to NA inhibitors","year":2019,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Shionogi; Canadian Institutes of Health Research; BioCryst","keywords":"Neuraminidase; Virology; Residue (chemistry); Influenzavirus B; Virus; Chemistry; Substitution (logic); Orthomyxoviridae; Influenza A virus; Microbiology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.009960584,0.0003747368,0.0005564898,0.0006617557,0.001368211,0.0004625822,0.0006796251,0.0002023254,0.00003073975],"category_scores_gemma":[0.01307628,0.0002273536,0.0001830754,0.002966928,0.001263687,0.0006299503,0.001073469,0.002198941,0.001470609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009257125,"about_ca_system_score_gemma":0.001278898,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009118218,"about_ca_topic_score_gemma":0.004180074,"domain_scores_codex":[0.9927105,0.001249396,0.0008445104,0.0009374256,0.002197242,0.002060964],"domain_scores_gemma":[0.9939752,0.002523948,0.000115921,0.001869413,0.001225095,0.0002904087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003086439,0.0002922228,0.1234872,0.0002773495,0.0001460255,0.0002480605,0.00319689,0.00003288995,0.8575621,0.000468419,0.008083195,0.003119278],"study_design_scores_gemma":[0.002513715,0.0009629942,0.5595508,0.000639141,0.00003639801,0.00002738404,0.00228707,0.0006148465,0.4272179,0.0003703801,0.005331855,0.0004474974],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989732,0.001055504,0.000002909589,0.003689385,0.0003079408,0.00343681,0.00002896622,0.00006743985,0.00167902],"genre_scores_gemma":[0.9970417,0.0002005683,0.0000130351,0.0005092258,0.0002644625,0.0001302592,0.00001382519,0.00005676708,0.001770175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4360636,"threshold_uncertainty_score":0.9999319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1199782056641034,"score_gpt":0.4380638959558294,"score_spread":0.318085690291726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}