{"id":"W2962396447","doi":"10.1016/j.celrep.2019.06.059","title":"Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Institut Universitaire en Santé Mentale de Québec; Université Laval; Hospital for Sick Children; University of Toronto","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; Fondation Brain Canada","keywords":"Downregulation and upregulation; Neuropathic pain; Neuroscience; Transporter; Medicine; Endocrinology; Biology; Internal medicine; Psychology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002068163,0.0003944062,0.0004085431,0.0003815833,0.000266577,0.0003754557,0.0003421404,0.0004570766,0.003023893],"category_scores_gemma":[0.0003043964,0.0001710216,0.000361613,0.0001269551,0.0004574561,0.0004347923,0.0003209065,0.0008135294,0.0005334413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002321667,"about_ca_system_score_gemma":0.0003648517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000576896,"about_ca_topic_score_gemma":0.001181098,"domain_scores_codex":[0.9997664,0.0000305118,0.00001933597,0.00006109071,0.00007049565,0.00005224946],"domain_scores_gemma":[0.9997074,0.00001935859,0.0001130403,0.00003092061,0.00003916418,0.00009000811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006796194,0.0001211654,0.004242353,0.0001253364,0.00002615871,0.0003054842,0.00006554133,0.0000421381,0.9886478,0.0003955411,0.0002100806,0.005138674],"study_design_scores_gemma":[0.0001753171,0.002526329,0.1448252,0.00007176046,0.000200968,0.004789374,0.0004920043,0.0008930858,0.8368203,0.0005555374,0.008601285,0.00004880719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900982,0.003621937,0.002280935,0.0004852758,0.0001236522,0.00003728395,0.0007085433,0.00009073172,0.002553467],"genre_scores_gemma":[0.9919939,0.001954615,0.0009356877,0.0003414513,0.00004079723,0.00006221886,0.0003558802,0.00004472801,0.00427066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003023893,"threshold_uncertainty_score":0.01011592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108652579375038,"score_gpt":0.2384708726203463,"score_spread":0.2276056146828425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}