{"id":"W2962482334","doi":"10.3389/fnins.2019.00742","title":"A Candidate Regulatory Variant at the TREM Gene Cluster Confer Alzheimer’s Disease Risk by Modulating Both Amyloid-β Pathology and Neuronal Degeneration","year":2019,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Inflammation biomarkers and pathways","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; Genentech; IXICO; National Natural Science Foundation of China; Pfizer; Novartis Pharmaceuticals Corporation; Meso Scale Diagnostics; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; BioClinica; Bristol-Myers Squibb; Eli Lilly and Company; Biogen; Foundation for the National Institutes of Health","keywords":"TREM2; Dementia; Alzheimer's Disease Neuroimaging Initiative; Cerebrospinal fluid; Pathogenesis; Disease; Neuroimaging; Internal medicine; Medicine; Alzheimer's disease; Amyloid (mycology); Oncology; Psychology; Pathology; Receptor; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004900944,0.0006755727,0.0004049041,0.0005667214,0.0003517889,0.0002712014,0.0003323954,0.0007768869,0.003651137],"category_scores_gemma":[0.0010595,0.0001778535,0.0006215673,0.0005823228,0.00024503,0.0001244938,0.0002311873,0.0003314369,0.0003377792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001318939,"about_ca_system_score_gemma":0.0001912024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001605944,"about_ca_topic_score_gemma":0.001629611,"domain_scores_codex":[0.9996921,0.0001081605,0.00003429664,0.0001007279,0.0000348577,0.00002996711],"domain_scores_gemma":[0.9993606,0.0002601922,0.0001865608,0.00006118996,0.00004848365,0.00008294041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01421153,0.0006252705,0.698014,0.0001836703,0.002356866,0.0101531,0.0006661867,0.001665027,0.2540275,0.001142498,0.001080071,0.01587444],"study_design_scores_gemma":[0.0002475353,0.0008306254,0.9814317,0.00003675199,0.0008380123,0.005289667,0.000159865,0.002767607,0.006784292,0.0007347082,0.000850227,0.0000290068],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999102,0.00009768851,0.0003546721,0.00003598431,0.000007491291,0.000005896232,0.0001879932,0.00001061776,0.0001977345],"genre_scores_gemma":[0.9989281,0.00003569465,0.0005121974,0.00003260665,0.00001295747,0.000007413649,0.000196989,0.000008108917,0.0002658864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003651137,"threshold_uncertainty_score":0.0122143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008404174014881369,"score_gpt":0.1997550338281931,"score_spread":0.1913508598133117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}