{"id":"W2962482334","doi":"10.3389/fnins.2019.00742","title":"A Candidate Regulatory Variant at the TREM Gene Cluster Confer Alzheimer’s Disease Risk by Modulating Both Amyloid-β Pathology and Neuronal Degeneration","year":2019,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Inflammation biomarkers and pathways","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; Genentech; IXICO; National Natural Science Foundation of China; Pfizer; Novartis Pharmaceuticals Corporation; Meso Scale Diagnostics; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; BioClinica; Bristol-Myers Squibb; Eli Lilly and Company; Biogen; Foundation for the National Institutes of Health","keywords":"TREM2; Dementia; Alzheimer's Disease Neuroimaging Initiative; Cerebrospinal fluid; Pathogenesis; Disease; Neuroimaging; Internal medicine; Medicine; Alzheimer's disease; Amyloid (mycology); Oncology; Psychology; Pathology; Receptor; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004580831,0.0001554574,0.0001630197,0.00007426107,0.0003775065,0.00003694207,0.0001935349,0.00009926501,0.00004253224],"category_scores_gemma":[0.00006077344,0.000116949,0.00003699611,0.000116893,0.0004236355,0.0001466655,0.0001360543,0.0001873071,0.00001697631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003049027,"about_ca_system_score_gemma":0.00005962825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002969652,"about_ca_topic_score_gemma":0.00002534005,"domain_scores_codex":[0.9983786,0.0004735254,0.0002503488,0.0005101128,0.00006588289,0.0003214797],"domain_scores_gemma":[0.9994073,0.00005281553,0.0001589335,0.0003201657,0.00001976359,0.00004103381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004061808,0.00003705695,0.1905403,0.000006760483,0.00001199939,0.00002843413,0.0004889615,0.0008564289,0.7905315,0.0002204196,0.01310494,0.003767048],"study_design_scores_gemma":[0.003558985,0.0003071226,0.8540409,0.00002341338,0.0001075293,0.0002691143,0.0001261606,0.04618139,0.05855973,0.0003381717,0.03581289,0.0006746059],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921585,0.001701663,0.00281988,0.0003334428,0.002336884,0.0003727834,0.0001421305,0.00002133689,0.00011333],"genre_scores_gemma":[0.9974371,0.0001314902,0.0001660756,0.001135543,0.00001873296,0.00002019191,0.00006121202,0.00001183717,0.001017822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7319718,"threshold_uncertainty_score":0.476904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008404174014881369,"score_gpt":0.1997550338281931,"score_spread":0.1913508598133117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}