{"id":"W2962507015","doi":"10.1016/j.ccell.2019.06.004","title":"M-TAP Dance: Targeting PRMT1 and PRMT5 Family Members to Push Cancer Cells Over the Edge","year":2019,"lang":"en","type":"letter","venue":"Cancer Cell","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Dance; Protein arginine methyltransferase 5; Cancer; Cancer research; Medicine; Biology; Genetics; Internal medicine; Art; Gene; Visual arts; Methyltransferase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001639166,0.0005317442,0.0003948425,0.00005142276,0.0001432372,0.0000901235,0.0004559426,0.001005532,0.0002685365],"category_scores_gemma":[0.00001197804,0.0004498865,0.0001774524,0.0001598689,0.0001256375,0.00001001487,0.0002737251,0.0007234262,0.00003056052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003823266,"about_ca_system_score_gemma":0.0005480933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001345853,"about_ca_topic_score_gemma":0.0004035616,"domain_scores_codex":[0.9974641,0.00009969182,0.000375258,0.001057313,0.0003560405,0.0006475977],"domain_scores_gemma":[0.9985988,0.00003550573,0.0003264887,0.0007861922,0.0001581498,0.00009490705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003026078,0.000006227131,0.000126123,0.0001847531,0.00008614529,0.000003360995,0.0001029424,0.001539285,0.2668993,4.016709e-7,0.7297754,0.001245866],"study_design_scores_gemma":[0.0004407032,0.0000658078,0.0003541857,0.0001022601,0.0001462135,0.000001886993,0.00003884577,0.0001077571,0.1004777,0.000002439238,0.8976948,0.0005673994],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.585168,0.2300941,0.0004203126,0.1394905,0.02068592,0.006954252,0.001849852,0.0001318568,0.01520526],"genre_scores_gemma":[0.06324682,0.0369634,0.0003601931,0.7517776,0.03991635,0.002362279,0.001744277,0.0007105836,0.1029185],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.6122871,"threshold_uncertainty_score":0.9997953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007459501505394685,"score_gpt":0.2401040704460576,"score_spread":0.232644568940663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}