{"id":"W2962507015","doi":"10.1016/j.ccell.2019.06.004","title":"M-TAP Dance: Targeting PRMT1 and PRMT5 Family Members to Push Cancer Cells Over the Edge","year":2019,"lang":"en","type":"letter","venue":"Cancer Cell","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Dance; Protein arginine methyltransferase 5; Cancer; Cancer research; Medicine; Biology; Genetics; Internal medicine; Art; Gene; Visual arts; Methyltransferase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002223691,0.0008663182,0.0009453902,0.0005443307,0.002662304,0.003391103,0.001213593,0.03821962,0.005296107],"category_scores_gemma":[0.00958893,0.0006043403,0.001200497,0.0003410482,0.002127701,0.001640163,0.001096093,0.0242564,0.004653685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004247145,"about_ca_system_score_gemma":0.002168214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003523484,"about_ca_topic_score_gemma":0.006087649,"domain_scores_codex":[0.9985883,0.0002993258,0.0001213326,0.0001825561,0.0005611318,0.0002473588],"domain_scores_gemma":[0.9977755,0.001244764,0.0001341033,0.00008870851,0.0003680228,0.0003889716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002382474,0.0000797785,0.0004223869,0.00006101897,0.00003219337,0.00183233,0.0000653157,0.000151387,0.001325456,0.004793566,0.9756528,0.01534544],"study_design_scores_gemma":[0.0004220147,0.0002400418,0.001255485,0.0001230792,0.00005588844,0.001618884,0.0002251821,0.00127044,0.002422603,0.0153578,0.9769332,0.00007528563],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.0009590082,0.002374218,0.0003885747,0.951588,0.03950762,0.0000352787,0.0001050393,0.00008207739,0.004960097],"genre_scores_gemma":[0.01332421,0.003166382,0.0008712813,0.8961109,0.04549557,0.0001365416,0.00009561983,0.00005754689,0.0407419],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.03821962,"threshold_uncertainty_score":0.0308153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007459501505394685,"score_gpt":0.2401040704460576,"score_spread":0.232644568940663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}