{"id":"W2962683137","doi":"10.1177/1352458519863133","title":"Biomarkers of intestinal barrier function in multiple sclerosis are associated with disease activity","year":2019,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Hotchkiss Brain Institute","keywords":"Occludin; Tight junction; Multiple sclerosis; Intestinal permeability; Neuroinflammation; Blood–brain barrier; Barrier function; Internal medicine; Dysbiosis; Endocrinology; Enterocyte; Chemistry; Medicine; Immunology; Biology; Central nervous system; Disease; Small intestine; Biochemistry; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003430957,0.0003848009,0.000535354,0.0008940827,0.0002522663,0.0004872399,0.0001929674,0.0004538924,0.001254962],"category_scores_gemma":[0.00138158,0.0001374329,0.0002164132,0.0009477906,0.0002504658,0.0002881187,0.0003532516,0.0004001325,0.0002119844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001967062,"about_ca_system_score_gemma":0.00009899514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008308633,"about_ca_topic_score_gemma":0.0008244669,"domain_scores_codex":[0.9997987,0.0000537075,0.00002932643,0.00004373365,0.00004442074,0.0000300438],"domain_scores_gemma":[0.9983695,0.0001756335,0.001107426,0.00004605777,0.0001328248,0.000168562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006037324,0.00004157957,0.9905505,0.0001199039,0.0001433812,0.0001562597,0.00007847145,0.00005188868,0.003709075,0.00001388512,0.00007005897,0.004461211],"study_design_scores_gemma":[0.000004879432,0.0001310906,0.9987405,0.000009918223,0.00004911602,0.0004961349,0.00003974594,0.00005557713,0.0003151471,0.00002682966,0.0001286168,0.000002566062],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996382,0.002932885,0.0001130792,0.00004057007,0.00000517483,0.000009669737,0.0002018975,0.00001296419,0.0003016421],"genre_scores_gemma":[0.9991873,0.0003570748,0.0001874967,0.00001201786,0.000008591901,0.000006793797,0.0001402223,0.000001650348,0.00009880464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001254962,"threshold_uncertainty_score":0.004198313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08007929884411687,"score_gpt":0.2318499991424467,"score_spread":0.1517707002983298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}