{"id":"W2962683137","doi":"10.1177/1352458519863133","title":"Biomarkers of intestinal barrier function in multiple sclerosis are associated with disease activity","year":2019,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Hotchkiss Brain Institute","keywords":"Occludin; Tight junction; Multiple sclerosis; Intestinal permeability; Neuroinflammation; Blood–brain barrier; Barrier function; Internal medicine; Dysbiosis; Endocrinology; Enterocyte; Chemistry; Medicine; Immunology; Biology; Central nervous system; Disease; Small intestine; Biochemistry; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004518174,0.0003273476,0.0004820093,0.0003565339,0.0003879775,0.0001109421,0.000262031,0.0001072319,0.0002160513],"category_scores_gemma":[0.002839949,0.0002593349,0.0001946457,0.000876162,0.0002668196,0.0006420832,0.0001080547,0.0005927855,0.0000231219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001892143,"about_ca_system_score_gemma":0.0001128305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005387208,"about_ca_topic_score_gemma":0.0002194682,"domain_scores_codex":[0.9974074,0.0003628906,0.0004817232,0.0005421407,0.0006968146,0.0005089738],"domain_scores_gemma":[0.9977081,0.0007591894,0.0006717738,0.0003181512,0.000226823,0.0003160049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00204205,0.0001659507,0.687662,0.00001763963,0.00005403113,0.000007608645,0.0001402887,0.0003458295,0.3066531,0.000003731322,0.0001835014,0.002724241],"study_design_scores_gemma":[0.004083739,0.0003045752,0.9585457,0.0005699277,0.00006081066,0.00001153639,0.0003017173,0.002421356,0.03327586,0.00003796602,0.00009015383,0.0002965944],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975318,0.00008348151,0.0007025328,0.0001724675,0.0008562301,0.000344555,0.0000948972,0.00006103556,0.0001529521],"genre_scores_gemma":[0.9993657,0.00006158144,0.0001134472,0.0002246983,0.00008145742,0.00002187631,0.000002742756,0.00003890516,0.00008954592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2733773,"threshold_uncertainty_score":0.9999859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08007929884411687,"score_gpt":0.2318499991424467,"score_spread":0.1517707002983298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}