{"id":"W2962726154","doi":"10.1002/ijc.32586","title":"Circulating tumor DNA quantity is related to tumor volume and both predict survival in metastatic pancreatic ductal adenocarcinoma","year":2019,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"Cancer Center Amsterdam; Ipsen; KWF Kankerbestrijding; Halozyme; Nordic Pharma Group; Celgene; Servier; Amgen; Pfizer; Eli Lilly and Company; GlaxoSmithKline","keywords":"Hazard ratio; Medicine; Confidence interval; Internal medicine; Circulating tumor DNA; Gastroenterology; Oncology; Adenocarcinoma; Proportional hazards model; Pancreatic ductal adenocarcinoma; Regimen; Pancreatic cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006227301,0.000206725,0.0003100765,0.0006212273,0.0001161835,0.0004021943,0.0001839243,0.0002301145,0.0006246429],"category_scores_gemma":[0.002751203,0.0001994264,0.0001995704,0.0003472313,0.0002070177,0.0002767488,0.0002910158,0.0002913928,0.0001217812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001646358,"about_ca_system_score_gemma":0.0001054026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006782816,"about_ca_topic_score_gemma":0.0006477,"domain_scores_codex":[0.9998049,0.00006091475,0.00002437651,0.00004352496,0.00004857765,0.00001766272],"domain_scores_gemma":[0.9987352,0.0005845591,0.0003580216,0.00009976698,0.00008536672,0.0001371119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004438034,0.0000141273,0.9927335,0.00001203128,0.00003396883,0.00008645638,0.00003867125,0.0002230997,0.002311279,0.00001196341,0.00002661697,0.004064349],"study_design_scores_gemma":[0.000009012361,0.0002290856,0.9971958,0.000004215261,0.0000350539,0.0005566237,0.00005095538,0.001093769,0.0006073252,0.00006635398,0.000147955,0.000003660885],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991783,0.0004132978,0.0002233161,0.00001213299,0.000002551761,0.00000203781,0.00005498702,0.000006339063,0.0001070906],"genre_scores_gemma":[0.9996098,0.00006709588,0.0001546403,0.000003775081,0.000005115378,0.000002596068,0.00009572029,0.000001611646,0.00005973599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006782816,"threshold_uncertainty_score":0.003293395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00879437862180661,"score_gpt":0.2770818012566287,"score_spread":0.2682874226348221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}