{"id":"W2962726154","doi":"10.1002/ijc.32586","title":"Circulating tumor DNA quantity is related to tumor volume and both predict survival in metastatic pancreatic ductal adenocarcinoma","year":2019,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"Cancer Center Amsterdam; Ipsen; KWF Kankerbestrijding; Halozyme; Nordic Pharma Group; Celgene; Servier; Amgen; Pfizer; Eli Lilly and Company; GlaxoSmithKline","keywords":"Hazard ratio; Medicine; Confidence interval; Internal medicine; Circulating tumor DNA; Gastroenterology; Oncology; Adenocarcinoma; Proportional hazards model; Pancreatic ductal adenocarcinoma; Regimen; Pancreatic cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002322719,0.0001125154,0.0002093065,0.0001098008,0.000015777,0.00004727538,0.0002048441,0.00002894049,0.0001356759],"category_scores_gemma":[0.0001476039,0.0001094991,0.00007660374,0.00006826944,0.00002758989,0.00001402676,0.00008949506,0.0001161415,0.000006208243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009634263,"about_ca_system_score_gemma":0.000247377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002972358,"about_ca_topic_score_gemma":0.000193869,"domain_scores_codex":[0.9989471,0.0000335994,0.0004090666,0.0001873604,0.0002771539,0.0001457534],"domain_scores_gemma":[0.9993083,0.00003319304,0.0002478125,0.0001038882,0.0002151934,0.00009161975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002732582,0.00004437926,0.9329234,0.00001852477,0.0003212726,0.0001596291,0.0001931573,0.001288539,0.06366455,0.000125897,0.0005320801,0.0004553332],"study_design_scores_gemma":[0.00257733,0.0004729078,0.9834802,0.0002212575,0.00009680337,0.0005768795,0.0002384795,0.001549903,0.006231511,0.0004014369,0.003878869,0.0002744081],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952312,0.002794093,0.0001169518,0.0005018376,0.001009816,0.0001218491,0.00007809146,0.000001832783,0.0001443569],"genre_scores_gemma":[0.9984934,0.0002574208,0.0002899901,0.0005565875,0.0002356008,0.000005227983,0.000008342849,0.00001728776,0.0001361436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05743304,"threshold_uncertainty_score":0.4465242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00879437862180661,"score_gpt":0.2770818012566287,"score_spread":0.2682874226348221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}