{"id":"W2962763649","doi":"","title":"Abstract #1291: Efficient knockdown of MMR proteins in human CRCcells using chained microRNA constructs","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Gene knockdown; MSH2; Microsatellite instability; KRAS; MLH1; MSH6; Cancer research; DNA mismatch repair; Biology; microRNA; Molecular biology; Mutation; Genetics; Cancer; Colorectal cancer; Gene; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006460783,0.0008064359,0.0007682581,0.0003230205,0.0003990986,0.0006040262,0.0005928792,0.0008434444,0.005922422],"category_scores_gemma":[0.0002128965,0.0005519573,0.0005489026,0.0004299011,0.0004405338,0.0003315776,0.0004059685,0.001510081,0.004534125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00055944,"about_ca_system_score_gemma":0.0004846379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007582501,"about_ca_topic_score_gemma":0.001701814,"domain_scores_codex":[0.9991639,0.0001126467,0.0001230959,0.0001794243,0.0003222824,0.0000986992],"domain_scores_gemma":[0.999783,0.00004175731,0.00005600043,0.00003910553,0.0000323843,0.00004769786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007557649,0.00004350929,0.00004861665,0.0001028602,0.000009023062,0.00005161129,0.0000391436,0.00005287821,0.997491,0.0002299401,0.0003909573,0.001464793],"study_design_scores_gemma":[0.0000410555,0.0002713356,0.0007811103,0.00001216344,0.00002061099,0.0002606765,0.00001492669,0.0007161107,0.979152,0.00003399542,0.0186882,0.0000077048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8256993,0.008445472,0.1101091,0.002371193,0.001607379,0.002425359,0.02504613,0.004075096,0.02022092],"genre_scores_gemma":[0.8503675,0.004080152,0.08169363,0.0005617289,0.0001383569,0.002067566,0.01880028,0.0008881843,0.04140268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005922422,"threshold_uncertainty_score":0.01981241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1075476045321842,"score_gpt":0.4355502714724933,"score_spread":0.3280026669403091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}