{"id":"W2962830434","doi":"10.1177/1934578x19860668","title":"Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives","year":2019,"lang":"en","type":"article","venue":"Natural Product Communications","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"","keywords":"Podophyllotoxin; Chemistry; Cell culture; Bromide; Cancer cell lines; Stereochemistry; Combinatorial chemistry; Cancer cell; Organic chemistry; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001792077,0.0001233455,0.0001773994,0.00004497414,0.00009253279,0.0000149396,0.0004289364,0.0000646243,0.000007222528],"category_scores_gemma":[0.0002642183,0.0001043829,0.00005583282,0.00008248725,0.0002484998,0.00001190721,0.0003342401,0.0001211076,0.000003288438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007346565,"about_ca_system_score_gemma":0.00003896346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003189952,"about_ca_topic_score_gemma":0.00003215353,"domain_scores_codex":[0.9992769,0.00009359609,0.0001726886,0.0002374315,0.00008929607,0.0001300483],"domain_scores_gemma":[0.9985836,0.0001312033,0.0001185002,0.001047931,0.00008980858,0.0000290219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002860472,0.0001093782,0.002412664,0.00002648476,0.00005344551,4.037873e-8,0.00005435181,0.000001676424,0.9947636,0.0004641526,0.00008324858,0.002002419],"study_design_scores_gemma":[0.0001300014,0.00004379823,0.02009216,0.00003613683,0.00001541597,0.00001071018,0.0001377077,0.00007798672,0.9763693,0.00002702513,0.002916748,0.000142975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994229,0.003067713,0.00003061722,0.0009819834,0.00004531353,0.0002591896,0.00008685575,0.00001177451,0.00128752],"genre_scores_gemma":[0.9933012,0.0006860758,0.005525852,0.00006459791,0.00003387587,0.00002326723,0.00004575818,0.00001204031,0.0003073208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0183942,"threshold_uncertainty_score":0.4256612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993710695390806,"score_gpt":0.2559417349821572,"score_spread":0.2360046280282491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}