{"id":"W2962830434","doi":"10.1177/1934578x19860668","title":"Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives","year":2019,"lang":"en","type":"article","venue":"Natural Product Communications","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"","keywords":"Podophyllotoxin; Chemistry; Cell culture; Bromide; Cancer cell lines; Stereochemistry; Combinatorial chemistry; Cancer cell; Organic chemistry; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006912157,0.0002776109,0.000204798,0.0001804291,0.0001083127,0.000179355,0.000132359,0.000165776,0.00143531],"category_scores_gemma":[0.00008597458,0.00008023278,0.0001642631,0.0001771523,0.00009506734,0.0002050859,0.0001447668,0.0003078135,0.0002954716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001209674,"about_ca_system_score_gemma":0.0001373596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000181415,"about_ca_topic_score_gemma":0.0004793205,"domain_scores_codex":[0.9999732,0.000005414656,0.000003538689,0.000005248961,0.000005586131,0.000007009165],"domain_scores_gemma":[0.9999613,0.000005361609,0.000009790077,0.000004901262,0.000007097784,0.00001155902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001450539,0.0001033419,0.0002759631,0.0002043233,0.0000118556,0.0003236428,0.0000401926,0.000841203,0.9866061,0.0005178736,0.00009366509,0.01083691],"study_design_scores_gemma":[0.00007769369,0.001868365,0.003366753,0.00003956155,0.00005203537,0.0005043441,0.00004714257,0.0008542057,0.9801979,0.0002583701,0.01271918,0.00001444951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761313,0.006907741,0.009417104,0.0001615091,0.00004460214,0.0001436782,0.001021338,0.00007808251,0.006094694],"genre_scores_gemma":[0.9813766,0.00613112,0.006980224,0.00007366528,0.00001736983,0.00007327214,0.001081322,0.00001168732,0.004254938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00143531,"threshold_uncertainty_score":0.004801571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993710695390806,"score_gpt":0.2559417349821572,"score_spread":0.2360046280282491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}