{"id":"W2962898942","doi":"10.1038/s41467-019-10945-z","title":"Non-coding variability at the APOE locus contributes to the Alzheimer’s risk","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Parkwood Institute; St Joseph's Health Care; University of British Columbia; McGill University; Jewish General Hospital","funders":"National Center for Advancing Translational Sciences; Nature; National Key Research and Development Program of China; National Institute of Mental Health; Shenzhen Knowledge Innovation Program; Medical Research Council; Chinese University of Hong Kong; National Institute on Aging; University Grants Committee; National Natural Science Foundation of China; Alzheimer's Disease Neuroimaging Initiative; Rosetrees Trust; Parkinson's UK","keywords":"Locus (genetics); Apolipoprotein E; Haplotype; Genetics; Biology; Alzheimer's disease; Disease; Gene; Neuroscience; Allele; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001517438,0.0001110803,0.00013721,0.00001774249,0.0006218502,0.00002505494,0.00123989,0.0003070446,0.00002832207],"category_scores_gemma":[0.001122593,0.00006694685,0.0001028723,0.0001762645,0.0001272946,0.00000179117,0.0009803206,0.000515223,0.00015043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003615026,"about_ca_system_score_gemma":0.00005608515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007550817,"about_ca_topic_score_gemma":0.001162874,"domain_scores_codex":[0.9987834,0.0004806677,0.0002164849,0.0002339268,0.00007438997,0.0002110951],"domain_scores_gemma":[0.9963282,0.0005502939,0.0001360466,0.002767927,0.0001777607,0.0000397777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000594484,0.0001518518,0.6321383,0.000004678437,0.0008001989,8.21961e-8,0.0003382977,0.001472368,0.03838111,0.008279691,0.3135003,0.004873676],"study_design_scores_gemma":[0.0002389278,0.00004308619,0.2064906,0.000004295727,0.0001043074,0.000002272844,0.0001151675,0.0006320883,0.00224999,0.0005035684,0.7894866,0.0001290899],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8383375,0.02189671,0.004700355,0.1144946,0.0009314255,0.00200777,0.0002739407,0.00003314931,0.01732457],"genre_scores_gemma":[0.994298,0.0007227109,0.0009404143,0.00297937,0.00007712883,0.00009879734,0.0001926743,0.00001103052,0.0006798547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4759863,"threshold_uncertainty_score":0.4782832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455313831600813,"score_gpt":0.2985891931251592,"score_spread":0.2840360548091511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}