{"id":"W2962898942","doi":"10.1038/s41467-019-10945-z","title":"Non-coding variability at the APOE locus contributes to the Alzheimer’s risk","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Parkwood Institute; St Joseph's Health Care; University of British Columbia; McGill University; Jewish General Hospital","funders":"National Center for Advancing Translational Sciences; Nature; National Key Research and Development Program of China; National Institute of Mental Health; Shenzhen Knowledge Innovation Program; Medical Research Council; Chinese University of Hong Kong; National Institute on Aging; University Grants Committee; National Natural Science Foundation of China; Alzheimer's Disease Neuroimaging Initiative; Rosetrees Trust; Parkinson's UK","keywords":"Locus (genetics); Apolipoprotein E; Haplotype; Genetics; Biology; Alzheimer's disease; Disease; Gene; Neuroscience; Allele; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005802374,0.0003495897,0.0003260784,0.0007834459,0.0003070078,0.0004789798,0.0003141288,0.0004645114,0.001912761],"category_scores_gemma":[0.001903208,0.0001726975,0.0003587245,0.0009779377,0.000352573,0.0001693155,0.0004254798,0.0005334498,0.0003250461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001051314,"about_ca_system_score_gemma":0.0001385654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002142319,"about_ca_topic_score_gemma":0.001495141,"domain_scores_codex":[0.9993774,0.000189807,0.00005392778,0.0002109718,0.0001158688,0.00005188643],"domain_scores_gemma":[0.9989499,0.0003917174,0.0003200409,0.0001596323,0.00008253515,0.00009615604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001565352,0.0001332054,0.9147003,0.00008217863,0.0007687631,0.00138724,0.000357012,0.0004238539,0.05422798,0.001519916,0.0005689556,0.02426537],"study_design_scores_gemma":[0.0000304861,0.0001169457,0.9914504,0.00002052651,0.0002274869,0.001919338,0.00009056092,0.0007089881,0.002611455,0.001805233,0.001005349,0.00001330954],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933361,0.001758292,0.00291422,0.0002252587,0.00003938937,0.00001310485,0.0003978045,0.00002981198,0.001285946],"genre_scores_gemma":[0.9986272,0.0003494557,0.0005448592,0.00003922909,0.00002674615,0.000004046723,0.0001760562,0.000008261269,0.0002241436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002142319,"threshold_uncertainty_score":0.006398857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455313831600813,"score_gpt":0.2985891931251592,"score_spread":0.2840360548091511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}