{"id":"W2963002070","doi":"10.1016/j.clinms.2019.07.003","title":"Detection and characterization of TDP-43 in human cells and tissues by multiple reaction monitoring mass spectrometry","year":2019,"lang":"en","type":"article","venue":"Clinical mass spectrometry","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Providence Health Care; Vancouver General Hospital; University of British Columbia","funders":"Alzheimer Society; Association for Frontotemporal Degeneration; Alzheimer's Drug Discovery Foundation","keywords":"Chemistry; Mass spectrometry; Western blot; Human brain; Tandem mass spectrometry; Amyotrophic lateral sclerosis; Nucleic acid; Multiplex; Characterization (materials science); Frontotemporal dementia; Computational biology; Molecular biology; Biology; Cell biology; Biochemistry; Dementia; Neuroscience; Pathology; Chromatography; Nanotechnology; Bioinformatics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007743059,0.0005823877,0.0003601178,0.0007642756,0.0003358787,0.0004231369,0.0003181873,0.0006737621,0.0005603165],"category_scores_gemma":[0.0007460894,0.0001765636,0.0001717752,0.0004322656,0.0003726844,0.0002150583,0.0002940292,0.0005985884,0.0005344781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002090546,"about_ca_system_score_gemma":0.0003962553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000587272,"about_ca_topic_score_gemma":0.0007338399,"domain_scores_codex":[0.9994465,0.00009675978,0.00003771488,0.0001967134,0.0001853978,0.00003693401],"domain_scores_gemma":[0.9997339,0.00007810007,0.00006030911,0.00003173517,0.00007253247,0.00002338546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007562018,0.00002933971,0.0006438991,0.00005147827,0.00001201073,0.0001361202,0.00007839451,0.00008423676,0.9921988,0.0001208094,0.0001697799,0.006399509],"study_design_scores_gemma":[0.00001290003,0.000195717,0.004454647,0.00001772093,0.00002848118,0.0009519569,0.00007276989,0.002656114,0.9868554,0.0002503722,0.004489785,0.00001410466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6465917,0.009366966,0.3324316,0.0007908916,0.0002200111,0.0005878778,0.002573983,0.00202621,0.005410872],"genre_scores_gemma":[0.7362185,0.006306566,0.2472524,0.0008424182,0.00008136722,0.001238334,0.001876778,0.0001747181,0.006008982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007743059,"threshold_uncertainty_score":0.004094958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03347130445703687,"score_gpt":0.3440998823800133,"score_spread":0.3106285779229764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}