{"id":"W2963158930","doi":"10.1093/jac/dkz306","title":"A β-lactamase-producing plasmid from Neisseria gonorrhoeae carrying a unique 6 bp deletion in blaTEM-1 encoding a truncated 24 kDa TEM-1 penicillinase that hydrolyses ampicillin slowly","year":2019,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Saskatchewan","keywords":"Neisseria gonorrhoeae; Plasmid; Microbiology; Ampicillin; Neisseriaceae; Biology; Amp resistance; Beta-lactamase; Cephalosporin; Neisseria; Escherichia coli; Bacteria; Genetics; Gene; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168187,0.0004539112,0.0002365766,0.000265268,0.0001485906,0.0001764448,0.00043876,0.0002429063,0.001030136],"category_scores_gemma":[0.0002238844,0.0001324248,0.0003220853,0.0004167296,0.0002386593,0.0001089754,0.0002596856,0.0004904858,0.0003265812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004789002,"about_ca_system_score_gemma":0.0006530025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005409606,"about_ca_topic_score_gemma":0.007080243,"domain_scores_codex":[0.9998587,0.00001392828,0.00001561912,0.00003690213,0.00004988612,0.00002490008],"domain_scores_gemma":[0.9998786,0.00002501606,0.00004084884,0.00001833862,0.00001207142,0.00002500457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003211689,0.0001572342,0.002823179,0.0001442949,0.00002251051,0.0002429168,0.00005412261,0.00007993291,0.988107,0.0001461047,0.0001335275,0.007767976],"study_design_scores_gemma":[0.0001958591,0.001819159,0.08212794,0.00006012171,0.0001878344,0.005555799,0.0001748061,0.001632126,0.8858745,0.0001185545,0.022219,0.00003420298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881322,0.0005201846,0.00709594,0.00007859854,0.00003775089,0.0002781733,0.002746729,0.0001069093,0.00100358],"genre_scores_gemma":[0.9478446,0.0006380946,0.03267408,0.00008367809,0.00001044183,0.0001274516,0.01510141,0.00004820081,0.003472175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005409606,"threshold_uncertainty_score":0.01075619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136908632344892,"score_gpt":0.237097417039688,"score_spread":0.2257283307162391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}