{"id":"W2963169617","doi":"10.1002/cbic.201900379","title":"A Fluorescence‐Based Assay for Screening β‐Lactams Targeting the <i>Mycobacterium tuberculosis</i> Transpeptidase Ldt<sub>Mt2</sub>","year":2019,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Wellcome Trust","keywords":"Mycobacterium tuberculosis; High-throughput screening; Antibiotics; Fluorophore; Tuberculosis; Resazurin; Enzyme; Chemistry; Potency; Microbiology; Fluorescence; Mycobacterium; Lipid II; Biochemistry; Combinatorial chemistry; Biology; Computational biology; Biosynthesis; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001077602,0.001328919,0.0005905564,0.0009536657,0.0004511242,0.000555812,0.0008549307,0.00132185,0.002001686],"category_scores_gemma":[0.0008698837,0.0004347786,0.0005564767,0.0008282729,0.0005009249,0.0003808149,0.0005022719,0.001180365,0.001098855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006718161,"about_ca_system_score_gemma":0.0004048084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007155045,"about_ca_topic_score_gemma":0.0009271023,"domain_scores_codex":[0.9986194,0.0005467269,0.00008212092,0.0002567403,0.0003444091,0.0001505704],"domain_scores_gemma":[0.9994373,0.0002015552,0.0001107946,0.00006153814,0.0001074766,0.00008131304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001215009,0.00008682486,0.0003542045,0.00006038712,0.00001163487,0.00002073374,0.00001291999,0.0001305878,0.9962442,0.0001124699,0.0001694806,0.002675139],"study_design_scores_gemma":[0.0000247068,0.0004034879,0.001263318,0.00001003769,0.00001621995,0.0001841258,0.00001127885,0.001838969,0.9947977,0.0000416345,0.001398316,0.00001017714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6232741,0.004803285,0.3510557,0.0006854393,0.0002858786,0.0008817434,0.004199472,0.002423727,0.01239055],"genre_scores_gemma":[0.7902952,0.002048374,0.1939234,0.000331877,0.00007474839,0.001049386,0.003689042,0.00009073635,0.008497206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002001686,"threshold_uncertainty_score":0.006696284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328602746457495,"score_gpt":0.2458181751930175,"score_spread":0.2325321477284426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}