{"id":"W2963171250","doi":"10.1002/cbic.201900344","title":"Replacing Mg<sup>2+</sup> by Fe<sup>2+</sup> for RNA‐Cleaving DNAzymes","year":2019,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Canada First Research Excellence Fund","keywords":"Deoxyribozyme; Chemistry; Ribozyme; Catalysis; Cofactor; DNA; RNA; Active site; Divalent; Enzyme; Metal; Stereochemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002172267,0.0003239704,0.0003153326,0.0000975189,0.00009438986,0.0003370937,0.0005241535,0.0004393422,0.001080255],"category_scores_gemma":[0.0002952644,0.0001332601,0.0002045356,0.0001470492,0.0002409845,0.0002523221,0.0001901415,0.0003436242,0.000485546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002591019,"about_ca_system_score_gemma":0.0001820051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007069898,"about_ca_topic_score_gemma":0.0007381035,"domain_scores_codex":[0.9998012,0.00003597077,0.00002978063,0.00004710707,0.0000487148,0.00003713123],"domain_scores_gemma":[0.9998335,0.00003510957,0.00005936258,0.00002713683,0.00002424436,0.00002073827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002094769,0.00001960792,0.0003479064,0.00008778514,0.00001075853,0.0000941966,0.00001491611,0.0002194852,0.9959436,0.00009086052,0.00006715178,0.002894205],"study_design_scores_gemma":[0.000007878753,0.0001011109,0.0004628969,0.000003434686,0.000008178913,0.00005699077,0.000007668862,0.0003674782,0.9964054,0.00002012282,0.002555746,0.000003251641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911423,0.001507208,0.005527261,0.0001800868,0.00006588666,0.00003503332,0.0002126389,0.0001570131,0.001172583],"genre_scores_gemma":[0.9905689,0.0003629919,0.007159743,0.00006404637,0.000006342635,0.00001867785,0.0002504147,0.00005318825,0.001515659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001080255,"threshold_uncertainty_score":0.00361377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007279917413911134,"score_gpt":0.2517772018232818,"score_spread":0.2444972844093707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}