{"id":"W2963254827","doi":"10.1002/art.41055","title":"Abatacept in Early Diffuse Cutaneous Systemic Sclerosis: Results of a Phase <scp>II</scp> Investigator‐Initiated, Multicenter, Double‐Blind, Randomized, Placebo‐Controlled Trial","year":2019,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Western University; Mount Sinai Hospital","funders":"National Center for Advancing Translational Sciences; U.S. National Library of Medicine; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Genentech; National Institutes of Health; Regeneron Pharmaceuticals; Kiniksa Pharmaceuticals; Cumberland Pharmaceuticals; University of Michigan; United Therapeutics Corporation; Gilead Sciences; Sanofi; Amgen; Pfizer; Bristol-Myers Squibb","keywords":"Placebo; Double blind; Medicine; Multiple sclerosis; Multicenter study; Internal medicine; Randomized controlled trial; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002643562,0.001457906,0.003049972,0.0003963696,0.0004197679,0.001100251,0.0006472524,0.001915309,0.004039253],"category_scores_gemma":[0.001763254,0.0004241067,0.001674515,0.0004493613,0.0005869432,0.0006732611,0.0002149218,0.001739567,0.0006560608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005014469,"about_ca_system_score_gemma":0.001119831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000595688,"about_ca_topic_score_gemma":0.001088225,"domain_scores_codex":[0.9991369,0.0004847878,0.00006879334,0.0001355854,0.00008310495,0.00009083268],"domain_scores_gemma":[0.9989464,0.0003409575,0.0002679879,0.000074906,0.0001226428,0.000247171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9661039,0.004623436,0.0007921075,0.001312481,0.00119598,0.00004197257,0.00004383073,0.0001857276,0.004013272,0.00005800689,0.0008439949,0.02078525],"study_design_scores_gemma":[0.9704739,0.02716624,0.001300097,0.00005045721,0.0003372938,0.00002709846,0.000006138445,0.0001056046,0.0002166706,0.00003229596,0.0002791095,0.000005062009],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759995,0.01391148,0.0007885757,0.0007326944,0.0006081385,0.004638088,0.001266639,0.0001538092,0.001901135],"genre_scores_gemma":[0.9765536,0.008170567,0.002326831,0.001481028,0.0008735516,0.006853065,0.001350846,0.00003231794,0.002358156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004039253,"threshold_uncertainty_score":0.01398063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02723608350363746,"score_gpt":0.2707733588221479,"score_spread":0.2435372753185104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}