{"id":"W2963254827","doi":"10.1002/art.41055","title":"Abatacept in Early Diffuse Cutaneous Systemic Sclerosis: Results of a Phase <scp>II</scp> Investigator‐Initiated, Multicenter, Double‐Blind, Randomized, Placebo‐Controlled Trial","year":2019,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Western University; Mount Sinai Hospital","funders":"National Center for Advancing Translational Sciences; U.S. National Library of Medicine; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Genentech; National Institutes of Health; Regeneron Pharmaceuticals; Kiniksa Pharmaceuticals; Cumberland Pharmaceuticals; University of Michigan; United Therapeutics Corporation; Gilead Sciences; Sanofi; Amgen; Pfizer; Bristol-Myers Squibb","keywords":"Placebo; Double blind; Medicine; Multiple sclerosis; Multicenter study; Internal medicine; Randomized controlled trial; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001354968,0.0006127779,0.00449547,0.0007282231,0.0001242902,0.00005033669,0.0003390854,0.0007370395,0.00004195846],"category_scores_gemma":[0.00486273,0.0005039879,0.0007979259,0.000495148,0.0005621082,0.000216302,0.0001456239,0.0005866764,0.0002718886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001032766,"about_ca_system_score_gemma":0.0005053669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001135131,"about_ca_topic_score_gemma":0.00008807273,"domain_scores_codex":[0.9927376,0.001189948,0.003570002,0.0009733259,0.0006304758,0.0008986644],"domain_scores_gemma":[0.9935149,0.00320443,0.00140036,0.0009288362,0.0002975213,0.0006539733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9821098,0.003033918,0.003077678,0.0003354983,0.0009376719,0.0002661551,0.003919272,0.00001811388,0.004524764,0.0002633932,0.0007036117,0.0008101469],"study_design_scores_gemma":[0.9768891,0.001903597,0.00004251047,0.01531759,0.0004257808,0.001689293,0.00153025,0.0007197671,0.001169541,0.00002860209,0.00006427155,0.0002197194],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9515093,0.03299052,0.00000659528,0.0001723744,0.00188506,0.01212602,0.00009455643,0.0001860948,0.001029461],"genre_scores_gemma":[0.9789498,0.01891605,0.00005189716,0.0001602448,0.00006849815,0.001267833,0.0001309871,0.00008831478,0.0003663253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02744053,"threshold_uncertainty_score":0.9997412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02723608350363746,"score_gpt":0.2707733588221479,"score_spread":0.2435372753185104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}