{"id":"W2963304872","doi":"10.1038/s41467-019-11140-w","title":"Active thrombin produced by the intestinal epithelium controls mucosal biofilms","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McMaster University","funders":"Canadian Institutes of Health Research; Région Occitanie Pyrénées-Méditerranée; Crohn's and Colitis Canada; Agence Nationale de la Recherche; Equipex; Centre National de la Recherche Scientifique; Alberta Innovates - Health Solutions","keywords":"Thrombin; Epithelium; Mucus; Microbiology; Intestinal mucosa; Biology; Biofilm; Cell biology; Intestinal epithelium; Mucin; Bacteria; Immunology; Biochemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002499457,0.0002280953,0.0002866764,0.0002178117,0.0001516882,0.0007413625,0.0001383555,0.0003841813,0.0006463431],"category_scores_gemma":[0.000266026,0.0001511716,0.0002077808,0.0001203631,0.0002394425,0.0002298755,0.0003544604,0.0005053142,0.0002466553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002466031,"about_ca_system_score_gemma":0.0002062696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003843695,"about_ca_topic_score_gemma":0.0003224196,"domain_scores_codex":[0.9996686,0.00008396996,0.00002520947,0.00006117526,0.00008493839,0.00007600254],"domain_scores_gemma":[0.9998022,0.00002490504,0.00006314614,0.0000196208,0.00003215978,0.00005794047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001210788,0.000007400662,0.0004370325,0.00002800796,0.000003370567,0.00004672289,0.00001670057,0.00002226213,0.9978822,0.00005270317,0.00003303554,0.001349521],"study_design_scores_gemma":[0.00002675277,0.0005243188,0.03424381,0.00002512464,0.00003460798,0.0005774172,0.0001934486,0.002069066,0.9582055,0.0002802577,0.003806675,0.00001307386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882616,0.005293047,0.004734596,0.0002330043,0.00004033998,0.00002456133,0.0002344844,0.00008645785,0.001091916],"genre_scores_gemma":[0.9960327,0.001116995,0.00164752,0.00006387704,0.00001440908,0.00001595766,0.0001379269,0.00001381108,0.0009569328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007413625,"threshold_uncertainty_score":0.002162278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108018308751178,"score_gpt":0.2574279094263875,"score_spread":0.2466260785512698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}