{"id":"W2963309491","doi":"10.1172/jci.insight.128008","title":"Primary tumors induce neutrophil extracellular traps with targetable metastasis-promoting effects","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":262,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Public Health Ontario; University of Toronto; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; American Association for Thoracic Surgery","keywords":"Neutrophil extracellular traps; Metastasis; Cancer research; Medicine; Cancer; Extracellular; Tumor microenvironment; Immune system; Primary tumor; Intravital microscopy; Circulating tumor cell; Cancer cell; Lung cancer; Immunology; Inflammation; Pathology; Biology; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001149819,0.0003424633,0.0002071354,0.0001737418,0.00009479495,0.0002416822,0.00008815854,0.0002217369,0.001931882],"category_scores_gemma":[0.00007494614,0.0001116186,0.0001793475,0.00007909149,0.0001155323,0.0001553083,0.0002393377,0.0006043959,0.0003282871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002503381,"about_ca_system_score_gemma":0.0001858651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004386078,"about_ca_topic_score_gemma":0.001360682,"domain_scores_codex":[0.9999167,0.00001195766,0.000003093391,0.00001281051,0.00002012082,0.00003532921],"domain_scores_gemma":[0.9999256,0.00001249493,0.00001850825,0.000006359244,0.000007484972,0.00002953776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001353265,0.00007683287,0.000157258,0.000041939,0.000005474279,0.00006166587,0.0000129399,0.00005346389,0.9969215,0.0001891916,0.0001542646,0.002190166],"study_design_scores_gemma":[0.00005286113,0.001247254,0.003988815,0.0000111051,0.00001836912,0.0003687359,0.0000331146,0.001161438,0.9892588,0.0001478424,0.003708383,0.000003279361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832036,0.004163035,0.007426629,0.00032733,0.00011263,0.0001541865,0.0004538894,0.0003046393,0.003853956],"genre_scores_gemma":[0.9922921,0.001005419,0.002336105,0.000100613,0.00001542659,0.00004612403,0.0003123345,0.00001850739,0.003873362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001931882,"threshold_uncertainty_score":0.006462753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007466157987769031,"score_gpt":0.1893486553715468,"score_spread":0.1818824973837777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}