{"id":"W2963314567","doi":"10.1016/j.ebiom.2019.07.054","title":"Emerging novel therapies against paracetamol (acetaminophen) hepatotoxicity","year":2019,"lang":"en","type":"letter","venue":"EBioMedicine","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Acetaminophen; Medicine; Acetylcysteine; Liver injury; Pharmacology; Antidote; acetaminophen overdose; Analgesic; Internal medicine; Toxicity; Chemistry; Antioxidant","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.001695274,0.001152135,0.001488419,0.0007849535,0.0005933826,0.0000616157,0.0009307306,0.004017138,0.002336452],"category_scores_gemma":[0.0001859937,0.001043833,0.0004573171,0.0007573491,0.0005930946,0.0002635521,0.0002274016,0.01008742,0.001974334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004222062,"about_ca_system_score_gemma":0.0002671677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001230056,"about_ca_topic_score_gemma":0.00001260854,"domain_scores_codex":[0.9944513,0.0008376069,0.001103759,0.001259071,0.00084802,0.001500279],"domain_scores_gemma":[0.9968793,0.0008863425,0.0008054983,0.0009520663,0.0002275224,0.0002492543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001665479,0.0003078919,0.0008255924,0.0009045151,0.001033849,0.0004588788,0.001413379,0.000051686,0.09400471,0.00004121264,0.8730595,0.02773225],"study_design_scores_gemma":[0.003041294,0.000265928,0.0002183096,0.000266836,0.0003624392,0.00009670494,0.0001102841,0.001514703,0.01246027,0.0001324636,0.9804484,0.001082365],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1079905,0.003467549,0.001310095,0.8318196,0.02563519,0.004431212,0.0008382479,0.001033633,0.02347405],"genre_scores_gemma":[0.09510043,0.001070814,0.0002296973,0.8625007,0.01731419,0.0003337698,0.00151778,0.0002434345,0.02168914],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1073889,"threshold_uncertainty_score":0.9992012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1237846205411338,"score_gpt":0.4025144070650046,"score_spread":0.2787297865238708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}