{"id":"W2963314567","doi":"10.1016/j.ebiom.2019.07.054","title":"Emerging novel therapies against paracetamol (acetaminophen) hepatotoxicity","year":2019,"lang":"en","type":"letter","venue":"EBioMedicine","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Acetaminophen; Medicine; Acetylcysteine; Liver injury; Pharmacology; Antidote; acetaminophen overdose; Analgesic; Internal medicine; Toxicity; Chemistry; Antioxidant","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004172631,0.0005237003,0.001049752,0.001236742,0.0002213453,0.0009018157,0.000744766,0.0009024191,0.008274457],"category_scores_gemma":[0.000538308,0.000148469,0.0008811645,0.0006296664,0.0002676856,0.00095958,0.0005669135,0.002044199,0.001870604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004262477,"about_ca_system_score_gemma":0.0005181012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005862472,"about_ca_topic_score_gemma":0.002285138,"domain_scores_codex":[0.9998009,0.00003775323,0.00001934106,0.00003120839,0.00007055788,0.00004027762],"domain_scores_gemma":[0.9997506,0.00005572701,0.00005001868,0.000007842384,0.0001051276,0.00003075898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007551286,0.0006683867,0.0007420063,0.01462188,0.000285173,0.000729283,0.0001349038,0.0004702809,0.0179224,0.006074884,0.04022587,0.91737],"study_design_scores_gemma":[0.0005617882,0.003257831,0.004364318,0.006926466,0.0007560761,0.002611279,0.0003385027,0.001024943,0.01005715,0.006734994,0.9633024,0.00006414816],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"editorial","genre_scores_codex":[0.005120618,0.9818943,0.001435132,0.003705363,0.0009088474,0.00005054521,0.0003082875,0.0001126263,0.006464212],"genre_scores_gemma":[0.03170946,0.9561688,0.002635729,0.003112448,0.001418254,0.0001010728,0.000693796,0.00002230263,0.004138077],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.008274457,"threshold_uncertainty_score":0.02768087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1237846205411338,"score_gpt":0.4025144070650046,"score_spread":0.2787297865238708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}