{"id":"W2963380471","doi":"10.1089/humc.2018.201","title":"The Landscape of Cellular and Gene Therapy Products: Authorization, Discontinuations, and Cost","year":2019,"lang":"en","type":"review","venue":"Human Gene Therapy Clinical Development","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Authorization; Cell therapy; Medicine; Genetic enhancement; Food and drug administration; Stem-cell therapy; Business; Pharmacology; Cell; Internal medicine; Gene; Biology; Computer science","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0101843,0.0002790034,0.0008476062,0.006565767,0.0007646038,0.004013875,0.0008508316,0.000881515,0.006653348],"category_scores_gemma":[0.06126514,0.0002773201,0.001290183,0.0157603,0.001223241,0.004524347,0.001024565,0.001388271,0.0005953534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004203411,"about_ca_system_score_gemma":0.002945924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004518977,"about_ca_topic_score_gemma":0.004926055,"domain_scores_codex":[0.9853307,0.004244819,0.003349347,0.001256549,0.005303803,0.0005147444],"domain_scores_gemma":[0.9058293,0.05633958,0.02958742,0.001134542,0.005678376,0.00143074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001748092,0.0003032681,0.2322537,0.02839389,0.001459185,0.001731042,0.001807187,0.001146418,0.0009231527,0.02405168,0.0497032,0.6564792],"study_design_scores_gemma":[0.0003383363,0.0009781066,0.5322174,0.03384505,0.002472854,0.0104306,0.008212131,0.001838871,0.001564453,0.01517513,0.3926879,0.0002390719],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.275641,0.6210185,0.002799558,0.02888333,0.0004874529,0.0004335682,0.01825838,0.00008239815,0.0523957],"genre_scores_gemma":[0.7481221,0.2325689,0.00347163,0.004936758,0.001004778,0.0004403281,0.007571019,0.00008009393,0.001804405],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0101843,"threshold_uncertainty_score":0.05386037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2059871115335652,"score_gpt":0.4292700288717852,"score_spread":0.22328291733822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}