{"id":"W2963489934","doi":"10.1021/jacs.9b03307","title":"An Asymmetric Reductase That Intercepts Acyclic Imino Acids Produced <i>in Situ</i> by a Partner Oxidase","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; Alfred P. Sloan Foundation","keywords":"Chemistry; Amino acid; Oxidase test; Stereochemistry; Imine; Mutagenesis; Reductase; Enzyme; In situ; Biochemistry; Organic chemistry; Catalysis; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000197568,0.0003251747,0.0001631904,0.0001278484,0.0001222467,0.0002294929,0.0003201505,0.0002959616,0.0005605069],"category_scores_gemma":[0.0001441389,0.0001292656,0.000176789,0.0001600643,0.0001495937,0.0002440403,0.0001598354,0.0003231295,0.0003192973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003162017,"about_ca_system_score_gemma":0.0001668628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007960715,"about_ca_topic_score_gemma":0.0007230568,"domain_scores_codex":[0.9998726,0.00001785591,0.000008170309,0.00004288774,0.00003974457,0.00001879748],"domain_scores_gemma":[0.9999387,0.000006194733,0.00002033553,0.000008052323,0.000009231077,0.00001740993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002820274,0.00001135586,0.0004425951,0.00003098289,0.000007586177,0.00005749326,0.00001446408,0.00008792774,0.9975272,0.0002644854,0.00003951141,0.001488197],"study_design_scores_gemma":[0.000003495727,0.00006088089,0.001374988,0.000001583644,0.000009438643,0.0002333961,0.00002118722,0.00117591,0.9942995,0.00003070991,0.002785334,0.000003543892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702811,0.001233342,0.02528437,0.0001117184,0.00003994188,0.00003021837,0.0002813498,0.0001890899,0.002548776],"genre_scores_gemma":[0.9829122,0.0003992706,0.01391767,0.00002054343,0.000005541118,0.000007577799,0.0004083423,0.00002508607,0.002303751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007960715,"threshold_uncertainty_score":0.002294242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007424611256050701,"score_gpt":0.2611856598275881,"score_spread":0.2537610485715374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}