{"id":"W2963503058","doi":"10.1172/jci120633","title":"Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences; National Institutes of Health; Chinese Academy of Agricultural Sciences; China Scholarship Council; National Institute of Mental Health; Robert Mapplethorpe Foundation; Crohn's and Colitis Foundation; U.S. Department of Defense","keywords":"Bromodomain; BRD4; Epigenetics; Chromatin; Provirus; Biology; Histone; BET inhibitor; Transactivation; Small molecule; Drug discovery; Virology; Transcription factor; Genetics; Bioinformatics; Genome; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001456208,0.0004058447,0.0002570849,0.0002933368,0.0001170236,0.0003542347,0.0003992595,0.0003671528,0.001232262],"category_scores_gemma":[0.00008643426,0.000163437,0.0002257456,0.0001454838,0.0001772337,0.0002184748,0.000279068,0.0003989797,0.0003607143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004709775,"about_ca_system_score_gemma":0.0002506585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003548659,"about_ca_topic_score_gemma":0.0009358026,"domain_scores_codex":[0.9999399,0.000009567035,0.000003746033,0.00001269519,0.00001753439,0.00001661567],"domain_scores_gemma":[0.9999788,0.000002337131,0.000006761513,0.000001850102,0.000004666087,0.000005616927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003348798,0.000288836,0.0003040028,0.000228507,0.00002679625,0.0001555147,0.00001880238,0.002019848,0.9637214,0.001874769,0.0007226638,0.03030399],"study_design_scores_gemma":[0.0006484433,0.003369843,0.00134587,0.00003670292,0.00007959936,0.0005416505,0.00002441379,0.009383974,0.956103,0.0005185593,0.02792465,0.00002342789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9141695,0.0161643,0.04628689,0.001193328,0.0002201408,0.0009754582,0.001204648,0.0005418173,0.01924391],"genre_scores_gemma":[0.9659481,0.007348537,0.01727363,0.0005838342,0.00002353601,0.0002222575,0.0009127414,0.00002129126,0.007666233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001232262,"threshold_uncertainty_score":0.004122317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09694265488467114,"score_gpt":0.3596081667909881,"score_spread":0.262665511906317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}