{"id":"W2963638759","doi":"10.1002/mc.23087","title":"Antitumour effects of metformin and curcumin in human papillomavirus positive and negative head and neck cancer cells","year":2019,"lang":"en","type":"article","venue":"Molecular Carcinogenesis","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Curcumin; Metformin; Biology; Head and neck squamous-cell carcinoma; Cancer; Cancer research; Apoptosis; Carcinogenesis; Cell; Cell growth; Cell culture; Drug; Head and neck cancer; Internal medicine; Pharmacology; Oncology; Medicine; Endocrinology; Diabetes mellitus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000108482,0.0002174556,0.0003715986,0.00008654266,0.00003885544,0.00001700831,0.00007715335,0.0001318588,0.000006941556],"category_scores_gemma":[0.00001854017,0.0002122441,0.00005701872,0.0001076099,0.000122316,0.000008770712,0.0001242584,0.00006295716,5.620159e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001280511,"about_ca_system_score_gemma":0.00004046047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008502482,"about_ca_topic_score_gemma":0.0001328115,"domain_scores_codex":[0.998868,0.0001072438,0.0001959148,0.0004536826,0.0001220664,0.0002530433],"domain_scores_gemma":[0.9995175,0.00002147098,0.00009100679,0.0002142255,0.00005911123,0.00009668833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004675319,0.00002836035,0.04003252,0.0002024144,0.00006920477,0.00001490471,0.0001855537,0.000007307603,0.9456769,0.00008307654,0.00001206069,0.01364096],"study_design_scores_gemma":[0.001382519,0.000240235,0.09487326,0.0000842128,0.00007276548,0.000004168141,0.00005508773,0.00001544869,0.9024913,0.00005981763,0.0004989845,0.0002222175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7709911,0.2284674,0.0000342299,0.000005924986,0.0000585389,0.0003274404,0.00003237691,0.00000279371,0.00008024504],"genre_scores_gemma":[0.9821169,0.01734622,0.0001652163,0.0002095488,0.00003126025,0.00004154601,0.00001340256,0.00002858826,0.00004735106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2111258,"threshold_uncertainty_score":0.8655062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004206163430925765,"score_gpt":0.2363453971661101,"score_spread":0.2321392337351843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}