{"id":"W2963664149","doi":"10.1039/c9nr02297j","title":"Ionizable amino lipid interactions with POPC: implications for lipid nanoparticle function","year":2019,"lang":"en","type":"article","venue":"Nanoscale","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); University of British Columbia; Burnaby Hospital; Calgary Laboratory Services; Simon Fraser University; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Compute Canada; Canada Foundation for Innovation; Alberta Innovates; Canadian Institutes of Health Research; British Columbia Innovation Council","keywords":"POPC; Cationic polymerization; Chemistry; Endosome; Biophysics; Vesicle; Small-angle X-ray scattering; Protonation; Cytoplasm; Nanoparticle; Molecular dynamics; Lipid bilayer; Nanotechnology; Biochemistry; Membrane; Polymer chemistry; Organic chemistry; Cell; Materials science; Computational chemistry; Scattering; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003140713,0.0007325243,0.0003397444,0.0002372572,0.0003474857,0.0006615259,0.0005225475,0.000829411,0.001280349],"category_scores_gemma":[0.0005110007,0.0001825975,0.000357027,0.0001841751,0.0006261106,0.0009286299,0.0004913735,0.000476317,0.0005488769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007499222,"about_ca_system_score_gemma":0.0002484311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001200098,"about_ca_topic_score_gemma":0.0003961671,"domain_scores_codex":[0.9997956,0.00002358144,0.00001379646,0.00005523275,0.00004383314,0.00006788952],"domain_scores_gemma":[0.9997538,0.00006012292,0.00008152711,0.00001986425,0.00005014139,0.00003456137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002391522,0.00002392831,0.0008792413,0.0001348705,0.00001697925,0.0004162187,0.00005547042,0.0006682536,0.9947811,0.0006817142,0.00009396829,0.00200914],"study_design_scores_gemma":[0.00001379575,0.00009603176,0.002508199,0.00001011371,0.00002371971,0.0003941132,0.00006124804,0.003324333,0.9915616,0.0004368843,0.001550216,0.00001972733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986856,0.003181423,0.00511784,0.0007840752,0.0000510052,0.00002926637,0.0001762183,0.00008832631,0.003715686],"genre_scores_gemma":[0.9968995,0.001065722,0.0009214318,0.0001532059,0.000009254286,0.00001486699,0.00008760482,0.00002668394,0.0008216368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001280349,"threshold_uncertainty_score":0.00544107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183166735779117,"score_gpt":0.2498275877307528,"score_spread":0.2379959203729616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}