{"id":"W2963664149","doi":"10.1039/c9nr02297j","title":"Ionizable amino lipid interactions with POPC: implications for lipid nanoparticle function","year":2019,"lang":"en","type":"article","venue":"Nanoscale","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); University of British Columbia; Burnaby Hospital; Calgary Laboratory Services; Simon Fraser University; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Compute Canada; Canada Foundation for Innovation; Alberta Innovates; Canadian Institutes of Health Research; British Columbia Innovation Council","keywords":"POPC; Cationic polymerization; Chemistry; Endosome; Biophysics; Vesicle; Small-angle X-ray scattering; Protonation; Cytoplasm; Nanoparticle; Molecular dynamics; Lipid bilayer; Nanotechnology; Biochemistry; Membrane; Polymer chemistry; Organic chemistry; Cell; Materials science; Computational chemistry; Scattering; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004873667,0.0001063502,0.00009471946,0.00003202416,0.0001047549,0.00003247709,0.0001149584,0.0000715791,0.00008873412],"category_scores_gemma":[0.00001450904,0.00009235134,0.00006708744,0.00008839319,0.00002826268,0.00001373623,0.00003666467,0.00004938921,0.0001515815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001508774,"about_ca_system_score_gemma":0.00004717685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001557951,"about_ca_topic_score_gemma":0.00008494344,"domain_scores_codex":[0.9992965,0.00001431077,0.0001351114,0.0002976893,0.00005110034,0.0002052545],"domain_scores_gemma":[0.9993746,0.00001373205,0.00005593865,0.0003472413,0.0001507561,0.00005768957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001962407,0.00008533459,0.01483548,0.000009681092,0.00003491541,5.096173e-8,0.00001674784,0.00006904574,0.9697283,0.0001553854,0.01282619,0.002042648],"study_design_scores_gemma":[0.0007768819,0.001432037,0.01623997,0.00002020728,0.00004111145,0.00001504374,0.0001054757,0.0001379836,0.7040219,0.00008172317,0.2769084,0.0002192863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909878,0.00007467271,0.005532525,0.0005679585,0.0004244267,0.0003380919,0.0000365014,0.00002313101,0.002014929],"genre_scores_gemma":[0.9855468,0.00002513899,0.000425136,0.0004032443,0.0002896377,0.0001368073,0.0001598776,0.00001932969,0.01299407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2657064,"threshold_uncertainty_score":0.3765978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183166735779117,"score_gpt":0.2498275877307528,"score_spread":0.2379959203729616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}