{"id":"W2963680999","doi":"10.1371/journal.pone.0219825","title":"Quick assessment for systematic test statistic inflation/deflation due to null model misspecifications in genome-wide environment interaction studies","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"DoD Alzheimer's Disease Neuroimaging Initiative; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Northern California Institute for Research and Education; University of California, San Diego; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; University of Southern California; Biogen; Bristol-Myers Squibb; Eisai; National Institute on Aging; Alzheimer's Association; Japan Society for the Promotion of Science; Foundation for the National Institutes of Health","keywords":"Null hypothesis; Test statistic; Statistical hypothesis testing; Statistic; Heritability; Covariate; Computer science; Null model; Instrumental variable; Gene–environment interaction; Statistics; Econometrics; Genetics; Biology; Machine learning; Mathematics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1058973,0.001229976,0.001619616,0.005497645,0.001106737,0.00268214,0.002381654,0.002257622,0.00563348],"category_scores_gemma":[0.5122527,0.0008213897,0.001805234,0.004388485,0.002381763,0.002831969,0.003828475,0.0032287,0.001033269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009862394,"about_ca_system_score_gemma":0.001908766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009648729,"about_ca_topic_score_gemma":0.001364104,"domain_scores_codex":[0.9330307,0.04080234,0.01001195,0.005235829,0.01025728,0.0006618573],"domain_scores_gemma":[0.4191754,0.5084549,0.03051418,0.02306688,0.01696795,0.001820745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002175695,0.0003030158,0.2767554,0.002407893,0.002102093,0.004620415,0.002531216,0.01518376,0.009893623,0.03263887,0.0279991,0.6233889],"study_design_scores_gemma":[0.001239645,0.00343491,0.245924,0.002625385,0.002894316,0.01682215,0.002128419,0.4118741,0.04403599,0.1973839,0.07080738,0.0008298106],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1009414,0.003713667,0.8802829,0.002935414,0.0006795137,0.001014872,0.001717982,0.005671215,0.003042997],"genre_scores_gemma":[0.3298716,0.000531907,0.6626396,0.001476434,0.0003096093,0.001328727,0.001642181,0.001249798,0.0009501019],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.1058973,"threshold_uncertainty_score":0.5600449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05499313547525706,"score_gpt":0.3051740620713743,"score_spread":0.2501809265961172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}