{"id":"W2963700022","doi":"10.3791/59385","title":"In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones","year":2019,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Deubiquitinating enzyme; Ubiquitin; Ubiquitin ligase; Cell biology; Ubiquitin-conjugating enzyme; Biology; Histone; Chromatin; DNA ligase; Biochemistry; Chemistry; Enzyme; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003816164,0.0001015136,0.0002203815,0.000134887,0.00001755727,0.00001135256,0.0001027295,0.00009890341,0.00005660843],"category_scores_gemma":[0.00006984024,0.0000969279,0.00006808178,0.00006425487,0.00003483034,0.00002238124,0.00005344043,0.00007258823,0.000002776816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002866278,"about_ca_system_score_gemma":0.00004877924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006938329,"about_ca_topic_score_gemma":5.332807e-7,"domain_scores_codex":[0.9990143,0.0001043248,0.0004231881,0.0001262027,0.0002075634,0.0001244023],"domain_scores_gemma":[0.9992883,0.0000151645,0.000404493,0.0000970297,0.000144231,0.0000508344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005599001,0.0001418661,0.001229985,0.00003313974,0.00002298145,0.000003377859,0.000363435,0.000002210051,0.9964541,0.0002616589,0.00008623238,0.0008410736],"study_design_scores_gemma":[0.002149753,0.0005301546,0.001345776,0.00004578377,0.000007234858,0.00003862502,0.0002558674,0.00005064988,0.9930867,0.0001220981,0.002271558,0.00009577718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997163,0.001099358,0.0001957773,0.00005738908,0.000192476,0.000146749,0.00000446569,0.000001890582,0.001138912],"genre_scores_gemma":[0.9978673,0.0001020513,0.001631151,0.0001101914,0.00009021934,0.000004307105,0.00001013638,0.00001397609,0.0001707003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003367417,"threshold_uncertainty_score":0.3952605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01487966829047745,"score_gpt":0.3592993328106484,"score_spread":0.3444196645201709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}