{"id":"W2963705735","doi":"10.1039/c9cc03942b","title":"DNA directed damage using a brominated DAPI derivative","year":2019,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health; Canadian Celiac Association; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DAPI; DNA; Fluorophore; Chemistry; Fluorescence; Photosensitizer; Derivative (finance); Halogenation; DNA damage; Photochemistry; Biophysics; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001277442,0.0001207496,0.0002648663,0.0000727934,0.0001163641,0.00001385602,0.0005003327,0.00007594413,0.0001350571],"category_scores_gemma":[0.0004265807,0.0001085951,0.00007092394,0.0004392409,0.0003305723,0.00006814385,0.0005711268,0.000432367,0.0000722332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002100593,"about_ca_system_score_gemma":0.00009239001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000054653,"about_ca_topic_score_gemma":0.000005100523,"domain_scores_codex":[0.9991211,0.0000906247,0.000195456,0.0001810205,0.0001758247,0.0002360077],"domain_scores_gemma":[0.9976519,0.0003862593,0.0000570467,0.001574829,0.0002159007,0.0001140307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005722468,0.0001792929,0.001151556,0.00002551852,0.0001130653,0.00000132124,0.0004250109,3.400189e-7,0.9973129,0.0001666351,0.0001953337,0.0003718277],"study_design_scores_gemma":[0.003270295,0.0001371335,0.02577853,0.0004138988,0.000124509,0.00003938911,0.0008883419,0.03196261,0.9268637,0.0006934456,0.00941053,0.0004175638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866874,0.0003968516,0.00002262892,0.001473892,0.00001718307,0.0004956572,0.0000218303,0.0001780406,0.01070656],"genre_scores_gemma":[0.9933635,0.0001600492,0.005348259,0.0001840117,0.00001338041,0.00003704814,0.0001503223,0.00002365917,0.0007197467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07044911,"threshold_uncertainty_score":0.4428379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05368392915233311,"score_gpt":0.3692980046740357,"score_spread":0.3156140755217026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}