{"id":"W2963705735","doi":"10.1039/c9cc03942b","title":"DNA directed damage using a brominated DAPI derivative","year":2019,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health; Canadian Celiac Association; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DAPI; DNA; Fluorophore; Chemistry; Fluorescence; Photosensitizer; Derivative (finance); Halogenation; DNA damage; Photochemistry; Biophysics; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009792546,0.0002504956,0.00011934,0.0001372386,0.0001135411,0.0001539933,0.0002632331,0.0003394778,0.002248011],"category_scores_gemma":[0.000140584,0.0001289062,0.0001021922,0.00009301678,0.0001712347,0.0001673573,0.0001591958,0.0003251809,0.0003376104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002249541,"about_ca_system_score_gemma":0.0001630839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006577324,"about_ca_topic_score_gemma":0.0009212646,"domain_scores_codex":[0.9999223,0.00001238396,0.00000399333,0.00002268525,0.00002098781,0.00001762041],"domain_scores_gemma":[0.9999235,0.00001897198,0.00002139548,0.000007101369,0.00001287766,0.00001618426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003075754,0.000008994237,0.00002537499,0.00004797477,0.000002030102,0.00004522321,0.00001132194,0.00009744403,0.9985977,0.0001198906,0.00003891828,0.0009744817],"study_design_scores_gemma":[0.00000758442,0.0002477401,0.0002725165,0.000005482676,0.000003885797,0.0001755317,0.000006770485,0.0003733326,0.9964444,0.00002579486,0.002433387,0.000003449191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9642181,0.003696661,0.02280513,0.0002722451,0.0000922789,0.00005966947,0.0003266497,0.0004368454,0.008092365],"genre_scores_gemma":[0.9841532,0.001260726,0.006607556,0.00009214972,0.000004679811,0.00001912557,0.0002449439,0.00002921807,0.007588304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002248011,"threshold_uncertainty_score":0.007520378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05368392915233311,"score_gpt":0.3692980046740357,"score_spread":0.3156140755217026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}