{"id":"W2963735786","doi":"10.1212/wnl.90.15_supplement.s38.001","title":"Preliminary Results from a Phase 2 Study to Evaluate ACE-083, a Local Muscle Therapeutic, in Patients with Facioscapulohumeral Muscular Dystrophy (S38.001)","year":2018,"lang":"en","type":"article","venue":"Neurology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; University of Calgary; London Health Sciences Centre","funders":"","keywords":"Facioscapulohumeral muscular dystrophy; Medicine; Muscular dystrophy; Physical therapy; Duchenne muscular dystrophy; Internal medicine; Physical medicine and rehabilitation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001559137,0.001045929,0.001016556,0.0001901715,0.0002739015,0.000481159,0.0004814487,0.0007465123,0.003094893],"category_scores_gemma":[0.001123191,0.0002301185,0.0008381802,0.0001960946,0.0004877646,0.0005009988,0.0002174542,0.001981126,0.0006376034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004274014,"about_ca_system_score_gemma":0.001006968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001198275,"about_ca_topic_score_gemma":0.003104413,"domain_scores_codex":[0.9995794,0.0002326127,0.00002130119,0.00004526378,0.00004564743,0.0000758012],"domain_scores_gemma":[0.9991861,0.0002380148,0.0001070608,0.00006770411,0.00006839298,0.0003327201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4639762,0.06302889,0.01839024,0.0008556653,0.00186294,0.001180834,0.0005494617,0.004251396,0.2168536,0.0005319028,0.007695618,0.2208233],"study_design_scores_gemma":[0.2037776,0.7312262,0.03613866,0.0000474525,0.0007630137,0.001080287,0.00009772259,0.001616033,0.01970607,0.0003236762,0.005182381,0.00004102362],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850087,0.00269168,0.002058075,0.0005839287,0.0001038226,0.002474098,0.001990161,0.0001510588,0.004938384],"genre_scores_gemma":[0.9856274,0.001358776,0.004036284,0.001119041,0.0001461834,0.002186532,0.002805652,0.00004856109,0.002671656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003094893,"threshold_uncertainty_score":0.01035339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009517652493718266,"score_gpt":0.2647922010223961,"score_spread":0.2552745485286779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}