{"id":"W2963802995","doi":"10.1158/1535-7163.mct-18-1337","title":"GnRH Antagonists Have Direct Inhibitory Effects On Castration-Resistant Prostate Cancer Via Intracrine Androgen and AR-V7 Expression","year":2019,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ferring; U.S. Department of Defense","keywords":"Prostate cancer; Testosterone (patch); Castration; Internal medicine; Endocrinology; Leuprorelin; Androgen deprivation therapy; LNCaP; Luteinizing hormone; Hormone; Medicine; Androgen; Enzalutamide; Chemistry; Androgen receptor; Cancer; Gonadotropin-releasing hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006480543,0.0002292583,0.0002078783,0.0001448958,0.00008370746,0.0002667481,0.000175724,0.0001058102,0.001609559],"category_scores_gemma":[0.00006405921,0.00008932787,0.0002039893,0.0001100769,0.0001275563,0.00007052351,0.00007790914,0.0003826996,0.0003981093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000143968,"about_ca_system_score_gemma":0.0002044747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000783969,"about_ca_topic_score_gemma":0.001536056,"domain_scores_codex":[0.999915,0.00001429863,0.00000605375,0.00001114201,0.00002776277,0.0000257229],"domain_scores_gemma":[0.9999579,0.000007293551,0.00001066343,0.000005677986,0.000005001462,0.00001349112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000290687,0.00007605171,0.000163846,0.00003703171,0.000009321485,0.00003806952,0.000008155247,0.00005517799,0.9964486,0.00004693053,0.0001379894,0.002688068],"study_design_scores_gemma":[0.00008127424,0.002454104,0.005836116,0.000007673151,0.00003608866,0.0003657835,0.00003824546,0.0004590892,0.9863548,0.00002069401,0.004341492,0.000004711243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932208,0.00295989,0.0004393929,0.0000686663,0.00004402017,0.00002244095,0.0003252998,0.00009383808,0.002825646],"genre_scores_gemma":[0.9938261,0.001475549,0.0005810005,0.00004515136,0.00001605821,0.00001908843,0.0007546491,0.00001943931,0.003262915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001609559,"threshold_uncertainty_score":0.005384505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493351646129815,"score_gpt":0.3093291308375101,"score_spread":0.2943956143762119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}