{"id":"W2963802995","doi":"10.1158/1535-7163.mct-18-1337","title":"GnRH Antagonists Have Direct Inhibitory Effects On Castration-Resistant Prostate Cancer Via Intracrine Androgen and AR-V7 Expression","year":2019,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ferring; U.S. Department of Defense","keywords":"Prostate cancer; Testosterone (patch); Castration; Internal medicine; Endocrinology; Leuprorelin; Androgen deprivation therapy; LNCaP; Luteinizing hormone; Hormone; Medicine; Androgen; Enzalutamide; Chemistry; Androgen receptor; Cancer; Gonadotropin-releasing hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001175149,0.0003274177,0.0003972965,0.0001168778,0.0001243611,0.00005875812,0.00008367391,0.0001301249,0.00008089553],"category_scores_gemma":[0.000004696652,0.0002474442,0.00009055114,0.0001560524,0.0001064911,0.00007848156,0.00005222502,0.0003046656,0.00001490364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003395352,"about_ca_system_score_gemma":0.0002740664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002089514,"about_ca_topic_score_gemma":0.00005420133,"domain_scores_codex":[0.9981459,0.00009876789,0.0002404985,0.0005358871,0.0005110588,0.000467857],"domain_scores_gemma":[0.9991263,0.00005364273,0.00009858741,0.0003864992,0.0001352385,0.0001997555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002175094,0.0001465679,0.02487279,0.0004616518,0.0003375489,0.0003139582,0.0005134344,0.00004258061,0.9271286,0.00001139102,0.0001028567,0.04389354],"study_design_scores_gemma":[0.004336148,0.001006522,0.008000308,0.0007201236,0.0001996853,0.00001557606,0.00005235008,0.0002443919,0.9748994,0.00006007203,0.01017147,0.0002939273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725848,0.02273069,0.00002356542,0.001724167,0.0003347746,0.001625443,0.00006489934,0.00006443646,0.0008472318],"genre_scores_gemma":[0.9916661,0.004751428,0.0001065818,0.001276397,0.0001678054,0.0003282003,0.00006039545,0.00007572358,0.00156734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04777085,"threshold_uncertainty_score":0.9999978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493351646129815,"score_gpt":0.3093291308375101,"score_spread":0.2943956143762119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}