{"id":"W2963825660","doi":"10.3389/fimmu.2019.01532","title":"Signaling Through gp130 Compromises Suppressive Function in Human FOXP3+ Regulatory T Cells","year":2019,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University Health Centre; McGill University","keywords":"FOXP3; Biology; Immunology; Population; Regulatory T cell; Cell biology; Immune system; Phenotype; IL-2 receptor; T cell; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001606363,0.0001736607,0.0002017442,0.0001500419,0.00007972166,0.0002293333,0.0001199271,0.0002073,0.0006260838],"category_scores_gemma":[0.000220526,0.00008145258,0.0001371679,0.000117226,0.0001694306,0.0001038722,0.0001294043,0.0003834881,0.0001962405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001461644,"about_ca_system_score_gemma":0.0001434504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005398403,"about_ca_topic_score_gemma":0.0003678307,"domain_scores_codex":[0.9998306,0.00003519797,0.00001145006,0.00002686889,0.00005274719,0.00004302137],"domain_scores_gemma":[0.9999131,0.00003265509,0.00001701624,0.00001608055,0.000005219773,0.00001583559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007365292,0.00001365707,0.000206225,0.00001092695,0.000002813111,0.00007641838,0.0000134676,0.00005448006,0.998183,0.00003605008,0.00001738763,0.001311973],"study_design_scores_gemma":[0.00004206112,0.0008540393,0.008647857,0.000004448227,0.00003188698,0.001328841,0.00003711725,0.001937469,0.9842438,0.00008437682,0.002783465,0.000004773717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998298,0.0005042425,0.0007486827,0.00003286535,0.000004602196,0.00001350052,0.00007632506,0.0000298478,0.000291966],"genre_scores_gemma":[0.9987842,0.000245968,0.000395967,0.0000227201,0.000005610902,0.00001163346,0.0002406125,0.000006512536,0.0002866509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006260838,"threshold_uncertainty_score":0.002094448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008639881619572031,"score_gpt":0.2099557480834345,"score_spread":0.2013158664638625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}