{"id":"W2963839877","doi":"10.1038/s41467-019-11306-6","title":"FDA-ARGOS is a database with public quality-controlled reference genomes for diagnostic use and regulatory science","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":332,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"U.S. Army Medical Research Institute of Infectious Diseases; U.S. National Library of Medicine; University of Colorado School of Medicine, Anschutz Medical Campus; DHHS Office of the Secretary; Defense Threat Reduction Agency; Hamilton Health Sciences Foundation; Public Health Agency; Children's National Hospital; British Columbia Centre for Disease Control; Public Health England; National Institutes of Health; U.S. Department of Health and Human Services; U.S. Department of Energy; U.S. Department of Defense","keywords":"Computer science; Quality (philosophy); Genome; Database; Computational biology; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03099634444729482,"score_gpt":0.3534364166572487,"score_spread":0.3224400722099539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."},"direct_labels":[],"classifier":{"requested":true,"available":true,"version":"metacan-v1-d91a1de5be90","frame_rows_covered":4299418,"decision_targets":["metaresearch","metaepi_narrow","metaepi_broad","bibliometrics","sts","scholarly_communication","open_science","research_integrity","randomized_trial","nonrandomized_trial","observational","systematic_review","meta_analysis","case_report","qualitative","simulation_or_modeling","bench_or_experimental","theoretical_or_conceptual","not_applicable"],"score_encoding":"uint16_le_65535","score_resolution":0.000015259021896696422,"interpretation":"Scores imitate each teacher on the enriched screening sample; they are not calibrated prevalence probabilities for the full frame.","warning":null},"prediction":{"classifier_version":"metacan-v1-d91a1de5be90","candidate_union":["metaresearch","scholarly_communication","observational","bench_or_experimental"],"consensus_intersection":["observational","bench_or_experimental"],"score_encoding":"uint16_le_65535","score_resolution":0.000015259021896696422,"scores":{"codex":{"metaresearch":0.004669260700389105,"metaepi_narrow":0,"metaepi_broad":0,"bibliometrics":0.00012207217517357137,"sts":0.0025482566567483025,"scholarly_communication":0.3615167467765316,"open_science":0.014496070801861601,"research_integrity":0.0007324330510414282,"randomized_trial":0.00006103608758678569,"nonrandomized_trial":0.000015259021896696422,"observational":0.8852368963149462,"systematic_review":0.0011444266422522317,"meta_analysis":0.000045777065690089265,"case_report":0.000045777065690089265,"qualitative":0.0003509575036240177,"simulation_or_modeling":0.00022888532845044633,"bench_or_experimental":0.10818646524757763,"theoretical_or_conceptual":0.0009308003356984818,"not_applicable":0.0520485236896315,"design_other":0.003341725795376516},"gemma":{"metaresearch":0.24228274967574578,"metaepi_narrow":0.000015259021896696422,"metaepi_broad":0,"bibliometrics":0.000015259021896696422,"sts":0.002609292744335088,"scholarly_communication":0.0009155413138017853,"open_science":0.0024414435034714275,"research_integrity":0.017975127794308383,"randomized_trial":0.00009155413138017853,"nonrandomized_trial":0.00012207217517357137,"observational":0.5932707713435569,"systematic_review":0.00019836728465705348,"meta_analysis":0.000030518043793392844,"case_report":0.000015259021896696422,"qualitative":0.0007629510948348211,"simulation_or_modeling":0.0019378957808804456,"bench_or_experimental":0.08471808957045854,"theoretical_or_conceptual":0.0024414435034714275,"not_applicable":0.023086900129701687}},"interpretation":"Scores imitate each teacher on the enriched screening sample; they are not calibrated prevalence probabilities for the full frame."}}