{"id":"W2963877669","doi":"10.3389/fgene.2019.00785","title":"Chicken or Egg: Is Clonal Hematopoiesis Primarily Caused by Genetic or Epigenetic Aberrations?","year":2019,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"RWTH Aachen University; Deutsche Krebshilfe; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Else Kröner-Fresenius-Stiftung; University of Lethbridge","keywords":"Epigenetics; Biology; Epigenome; Chromatin; Somatic evolution in cancer; Genetics; Epigenetic therapy; Mutation; DNA methylation; Cancer; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003617579,0.001079285,0.00200746,0.0003916235,0.0001548709,0.0001464818,0.001012582,0.001556792,0.0001749779],"category_scores_gemma":[0.0001581143,0.0009033539,0.0005689736,0.0006678877,0.000207184,0.000007281578,0.0003767678,0.0005046891,0.00007548839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000193525,"about_ca_system_score_gemma":0.00155712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001657178,"about_ca_topic_score_gemma":0.00008033421,"domain_scores_codex":[0.9949142,0.000413862,0.001637643,0.00155314,0.0005731607,0.000907999],"domain_scores_gemma":[0.9971173,0.00007931205,0.0007312686,0.001632601,0.0001633277,0.0002762355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001755661,0.000407439,0.001927323,0.009315341,0.001056175,0.00003962159,0.0002144272,0.0002139717,0.0009094144,0.000004520346,0.1203131,0.8654231],"study_design_scores_gemma":[0.0007661939,0.0005495668,0.0001560979,0.0008916361,0.0007059658,0.00001624863,0.00003751889,0.0001497934,0.002281585,0.0000736174,0.9931445,0.001227316],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007922984,0.9836447,0.01081777,0.00004061932,0.001792882,0.001988343,0.0005489456,0.00002529908,0.000349123],"genre_scores_gemma":[0.00006488171,0.9680823,0.0196229,0.0002062823,0.000495818,0.0002835047,0.001702023,0.0002745541,0.009267744],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8728314,"threshold_uncertainty_score":0.9997394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03752484450326594,"score_gpt":0.3198473563867945,"score_spread":0.2823225118835286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}