{"id":"W2963889829","doi":"10.1080/19420862.2019.1632114","title":"Binding symmetry and surface flexibility mediate antibody self-association","year":2019,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; National Research Council Canada","funders":"National Research Council Canada; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Research Foundation; Canadian Light Source","keywords":"Chemistry; Protein engineering; In silico; Monoclonal antibody; Docking (animal); Protein Data Bank (RCSB PDB); Hydrophobic effect; Computational biology; Monomer; Protein structure; Biophysics; Crystallography; Antibody; Stereochemistry; Biochemistry; Biology; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005658077,0.0003545272,0.0004466316,0.0001727457,0.0003763413,0.000779153,0.0004905015,0.0004189692,0.001941063],"category_scores_gemma":[0.001737464,0.0002939734,0.0003457173,0.0001517641,0.0004059447,0.0008245242,0.0006967036,0.0006268866,0.0006046794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003509533,"about_ca_system_score_gemma":0.0003814845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003393477,"about_ca_topic_score_gemma":0.0003347432,"domain_scores_codex":[0.9996809,0.00007403746,0.00001992543,0.00004732689,0.0001105555,0.00006729401],"domain_scores_gemma":[0.9994523,0.0002223684,0.0001136945,0.00008892117,0.00006724539,0.00005559283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004160401,0.0001630819,0.008649386,0.0001765779,0.00005188565,0.0003738618,0.0002024153,0.02258363,0.9219306,0.01239574,0.0004737276,0.03258294],"study_design_scores_gemma":[0.00006087428,0.0004415715,0.01367474,0.00001842687,0.0000503552,0.0008259632,0.0001636143,0.2739004,0.6946972,0.01235601,0.003772612,0.00003823763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679584,0.0003685548,0.02794797,0.0001166885,0.00001887752,0.00003333006,0.00004047742,0.0001600951,0.003355501],"genre_scores_gemma":[0.9951158,0.0001125383,0.004205721,0.00002832435,0.000003675748,0.000009238036,0.00005759738,0.00001763314,0.000449486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001941063,"threshold_uncertainty_score":0.006493449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440212094633236,"score_gpt":0.3183102044220189,"score_spread":0.3039080834756865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}