{"id":"W2963915797","doi":"10.1124/dmd.119.087981","title":"The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions","year":2019,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Metabolite; Inflammasome; Carbamazepine; Chemistry; Immune system; Pharmacology; Programmed cell death; Biochemistry; Biology; Apoptosis; Immunology; Receptor; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003569792,0.000522413,0.0003344817,0.0003182194,0.0001983867,0.0006338892,0.0001813806,0.0004375529,0.00243547],"category_scores_gemma":[0.0003288061,0.0001741243,0.0003672379,0.0001996739,0.0002665904,0.0004151052,0.0001916892,0.0007956867,0.0004978912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002329197,"about_ca_system_score_gemma":0.0002605027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004917837,"about_ca_topic_score_gemma":0.0007005743,"domain_scores_codex":[0.999719,0.00008347166,0.00003017791,0.00003443212,0.00006838,0.00006454183],"domain_scores_gemma":[0.9998263,0.00004940966,0.00004427073,0.00002921062,0.00001849817,0.0000324959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005116475,0.00003808864,0.0005507771,0.00003270365,0.00001499031,0.0002674513,0.00002098562,0.00003036228,0.9974037,0.0001102618,0.00003226523,0.0009868369],"study_design_scores_gemma":[0.00003095537,0.0002669835,0.004836044,0.000005564228,0.00001384229,0.0003765239,0.00004497147,0.0003390185,0.9932909,0.00007327853,0.0007168399,0.000005191636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868471,0.00330204,0.006073039,0.0004648718,0.0001961735,0.00008728824,0.0004352118,0.00009006997,0.002504138],"genre_scores_gemma":[0.9934623,0.0011362,0.002690222,0.00009931371,0.00007440163,0.00004038309,0.0005352903,0.00001618353,0.001945738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00243547,"threshold_uncertainty_score":0.008147478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00732840982711815,"score_gpt":0.2275827243412748,"score_spread":0.2202543145141566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}