{"id":"W2963915797","doi":"10.1124/dmd.119.087981","title":"The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions","year":2019,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Metabolite; Inflammasome; Carbamazepine; Chemistry; Immune system; Pharmacology; Programmed cell death; Biochemistry; Biology; Apoptosis; Immunology; Receptor; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002948575,0.0002380148,0.0003538339,0.00006091556,0.0002513594,0.00003494633,0.0001870457,0.0001054595,0.000004702701],"category_scores_gemma":[0.0001502482,0.0001267752,0.0001346588,0.0001872319,0.0001626725,0.00004411493,0.00007762859,0.0001035605,8.534781e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001032675,"about_ca_system_score_gemma":0.00009829795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000853663,"about_ca_topic_score_gemma":0.0003635141,"domain_scores_codex":[0.9987009,0.0001297843,0.0004299346,0.0003424078,0.0001555199,0.0002414669],"domain_scores_gemma":[0.9984055,0.0002395419,0.0003398062,0.000607072,0.0003589854,0.00004907287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008365088,0.0000638195,0.004634051,0.00004390174,0.0002569917,1.567744e-7,0.0003999498,0.00005531035,0.9880646,0.001973382,0.00001627017,0.003655013],"study_design_scores_gemma":[0.001624306,0.0001873488,0.2032432,0.00004185886,0.0003342138,0.000007572263,0.001424554,0.0002988322,0.7871668,0.000550141,0.004880715,0.0002404671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943372,0.002793999,0.0002487795,0.0008088037,0.0001420027,0.0009284414,0.0005864933,0.00001157553,0.0001427029],"genre_scores_gemma":[0.9964783,0.001768692,0.0001511276,0.00006199921,0.0001425843,0.0001515789,0.001092205,0.00002902748,0.0001244412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2008979,"threshold_uncertainty_score":0.5169742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00732840982711815,"score_gpt":0.2275827243412748,"score_spread":0.2202543145141566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}