{"id":"W2963918876","doi":"10.1016/j.celrep.2019.06.062","title":"Platelets Promote Macrophage Polarization toward Pro-inflammatory Phenotype and Increase Survival of Septic Mice","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Fondo para la Investigación Científica y Tecnológica; Agencia Nacional de Promoción Científica y Tecnológica; Heart and Stroke Foundation of Canada; Cumming School of Medicine, University of Calgary; Consejo Nacional de Investigaciones Científicas y Técnicas; University of Calgary; Canada Research Chairs","keywords":"Lipopolysaccharide; Integrin alpha M; Platelet; CD163; Sepsis; Macrophage; Macrophage polarization; Immunology; Platelet activation; Tumor necrosis factor alpha; Effector; Inflammation; Phagocytosis; Biology; In vitro; Flow cytometry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000229552,0.0003211958,0.0002603507,0.000254583,0.00009555522,0.0002449684,0.00009782243,0.0002418749,0.0009438862],"category_scores_gemma":[0.000121682,0.00009745271,0.0001536025,0.0001193321,0.0001514894,0.0001812901,0.0001648663,0.0006777314,0.0002358611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008106521,"about_ca_system_score_gemma":0.0001224662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007348516,"about_ca_topic_score_gemma":0.0001282286,"domain_scores_codex":[0.999848,0.0000517368,0.00001289155,0.00001714834,0.00002995921,0.00004028132],"domain_scores_gemma":[0.9999017,0.00001686767,0.00003026324,0.00001040379,0.00001136232,0.00002945011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001218,0.0001641071,0.000321402,0.00005190044,0.000005830064,0.00009093632,0.00003327624,0.00006416378,0.994505,0.0001141892,0.00008555574,0.003345696],"study_design_scores_gemma":[0.0001086221,0.005219209,0.007583357,0.00001980479,0.00004241765,0.0004219287,0.00007674869,0.0009223674,0.9827344,0.0001494094,0.002713588,0.000008106227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950872,0.001865708,0.001694439,0.0001651374,0.0000333245,0.00002343203,0.0001896749,0.000045252,0.0008958922],"genre_scores_gemma":[0.9947413,0.00135676,0.001546778,0.0001111776,0.00003301653,0.0000628319,0.0002370139,0.00001360308,0.001897383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009438862,"threshold_uncertainty_score":0.003157675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006423932086392321,"score_gpt":0.2090492581347504,"score_spread":0.2026253260483581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}