{"id":"W2963934574","doi":"10.1093/toxsci/kfz158","title":"DNA Damage and Perturbed Topoisomerase IIα as a Target of 1,4-Benzoquinone Toxicity in Murine Fetal Liver Cells","year":2019,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Queen's University","keywords":"Toxicity; Oxidative stress; Metabolite; DNA damage; In utero; Chemistry; Fetus; Population; Carcinogen; Glutathione; Molecular biology; Biology; Biochemistry; DNA; Enzyme; Medicine; Genetics; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000140508,0.0003728658,0.0002139414,0.000316608,0.0001200212,0.0001872838,0.0001533396,0.0002662133,0.001187826],"category_scores_gemma":[0.0001030639,0.0001918329,0.0002434024,0.0001866647,0.0001579969,0.0001559504,0.0001359799,0.0004515421,0.0003251788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002245799,"about_ca_system_score_gemma":0.0001295296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001433493,"about_ca_topic_score_gemma":0.00129124,"domain_scores_codex":[0.9998356,0.00002736674,0.00001459341,0.00003880317,0.00005021585,0.0000334561],"domain_scores_gemma":[0.9998879,0.00001828328,0.00003589507,0.0000175098,0.00002152763,0.00001879429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004895562,0.000006058211,0.0001197167,0.00001351384,0.000001887557,0.00002482012,0.00001429936,0.00001623339,0.9995255,0.000009551522,0.000005260228,0.000214172],"study_design_scores_gemma":[0.000004901919,0.0004037249,0.00773553,0.000005234363,0.00001215083,0.0001877386,0.00003635871,0.0002375099,0.9905026,0.00001642267,0.0008548266,0.00000295867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892865,0.004401946,0.004368094,0.00009904106,0.0000348962,0.00002737454,0.0007537029,0.00009047035,0.0009379894],"genre_scores_gemma":[0.9937841,0.001461458,0.001579271,0.00004090092,0.000008351338,0.00002796912,0.0008880971,0.00001218852,0.002197735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001433493,"threshold_uncertainty_score":0.003973663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01346334603951052,"score_gpt":0.2564146060206103,"score_spread":0.2429512599810998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}