{"id":"W2963934574","doi":"10.1093/toxsci/kfz158","title":"DNA Damage and Perturbed Topoisomerase IIα as a Target of 1,4-Benzoquinone Toxicity in Murine Fetal Liver Cells","year":2019,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Queen's University","keywords":"Toxicity; Oxidative stress; Metabolite; DNA damage; In utero; Chemistry; Fetus; Population; Carcinogen; Glutathione; Molecular biology; Biology; Biochemistry; DNA; Enzyme; Medicine; Genetics; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003084106,0.0001083706,0.0001720563,0.00003692091,0.00004691285,0.0000192714,0.0002020304,0.000114519,0.000449628],"category_scores_gemma":[0.00002386428,0.00007879984,0.00004551737,0.0001335338,0.0002471812,0.000007095344,0.0001712585,0.00006623509,0.000008563327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001039054,"about_ca_system_score_gemma":0.00004819438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005033223,"about_ca_topic_score_gemma":0.0000639493,"domain_scores_codex":[0.9990651,0.0000503995,0.0001547373,0.0003488395,0.0001472157,0.000233731],"domain_scores_gemma":[0.9996946,0.00002595881,0.00005924105,0.0001240445,0.00002068838,0.00007542071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006332085,0.0001286181,0.0009640325,0.000008850498,0.000005228487,0.000005080266,0.00004685462,0.00003407185,0.9970545,0.0006745085,0.00001913358,0.000995804],"study_design_scores_gemma":[0.0005239004,0.002181948,0.006194139,0.000007989107,0.000004253419,0.000006621325,0.0001305359,0.0005558381,0.9864667,0.0007695441,0.003007412,0.0001511232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971846,0.0004403663,0.00003995253,0.0002020337,0.0001032667,0.0002037034,0.00001006198,0.000005078611,0.00181089],"genre_scores_gemma":[0.9976618,0.000210662,0.0007749347,0.0008093275,0.00003588849,0.00000722818,0.000003835297,0.00000356362,0.000492795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0105878,"threshold_uncertainty_score":0.4923111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01346334603951052,"score_gpt":0.2564146060206103,"score_spread":0.2429512599810998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}