{"id":"W2963951165","doi":"10.1016/s1473-3099(19)30266-x","title":"Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":322,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"INOVIO Pharmaceuticals; Henry M. Jackson Foundation; Walter Reed Army Institute of Research; Ministry of Land and Resources of the People's Republic of China; U.S. Department of Defense","keywords":"Medicine; Adverse effect; Middle East respiratory syndrome coronavirus; Tolerability; Immunogenicity; Clinical trial; Vaccination; Internal medicine; Immunology; Antibody; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002276029,0.002140617,0.002283426,0.0003925451,0.0004289017,0.001235514,0.0009023946,0.00216128,0.003333141],"category_scores_gemma":[0.001881663,0.0006196718,0.001531794,0.0003252196,0.001535091,0.001599058,0.0003607786,0.004141505,0.0008517007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001046707,"about_ca_system_score_gemma":0.001081239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004286481,"about_ca_topic_score_gemma":0.0004868038,"domain_scores_codex":[0.9989517,0.0004645305,0.0000508572,0.0002307215,0.0001046736,0.0001975698],"domain_scores_gemma":[0.9987351,0.0003521718,0.0003161698,0.0001312204,0.00008431826,0.0003809358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8975381,0.03731869,0.002032964,0.0004881107,0.001082917,0.0000761591,0.0002130101,0.001422726,0.01657145,0.0002345499,0.001273661,0.0417477],"study_design_scores_gemma":[0.608082,0.3831646,0.004051132,0.00002964736,0.0003386514,0.00007516482,0.00004151352,0.0009055767,0.001987047,0.0003026955,0.0009921454,0.00002976419],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961191,0.001007671,0.0004225078,0.0003242391,0.000165924,0.0007948556,0.000461654,0.0000406833,0.0006633501],"genre_scores_gemma":[0.9937529,0.000734503,0.0009257447,0.0007528972,0.0002187402,0.001293145,0.0008583567,0.0000226882,0.001441144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003333141,"threshold_uncertainty_score":0.01203698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1113802047115747,"score_gpt":0.3797049138229072,"score_spread":0.2683247091113324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}