{"id":"W2963978412","doi":"10.1016/j.omto.2019.07.003","title":"Coxsackievirus Type B3 Is a Potent Oncolytic Virus against KRAS-Mutant Lung Adenocarcinoma","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; St. Paul's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC; Terry Fox Research Institute; University of British Columbia; Canadian Lung Association; BC Cancer Foundation; Vancouver Coastal Health Research Institute; British Columbia Lung Association; Canadian Institutes of Health Research; Mitacs; International Association for the Study of Lung Cancer","keywords":"Oncolytic virus; KRAS; Virology; Adenocarcinoma; Coxsackievirus; Mutant; Cancer research; Virus; Biology; Mutation; Medicine; Enterovirus; Internal medicine; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005865202,0.0006712392,0.0006064777,0.0001987523,0.0001750277,0.0001472242,0.001015415,0.0005273944,0.0004051624],"category_scores_gemma":[0.00005814003,0.000658976,0.0004324607,0.0005824389,0.0001781236,0.00001478987,0.0002916445,0.0005055974,0.0008528697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002975065,"about_ca_system_score_gemma":0.0008307475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004472977,"about_ca_topic_score_gemma":0.00003617846,"domain_scores_codex":[0.9958605,0.0003173382,0.0006285058,0.001162606,0.0009457272,0.001085284],"domain_scores_gemma":[0.9970009,0.00003198335,0.0002375233,0.001905429,0.0004184023,0.0004057241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003788114,0.0003703152,0.001354522,0.00004555,0.0005281522,0.0001506508,0.0001691724,0.0003681185,0.9727174,0.000031321,0.001571892,0.01890479],"study_design_scores_gemma":[0.003646017,0.006520385,0.0004158271,0.00005305016,0.00004823608,0.00003913964,0.00007389177,0.00220931,0.936843,0.00006167654,0.04923213,0.0008573193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774651,0.01677121,0.0003616089,0.0004594074,0.0005329808,0.001576536,0.00007165863,0.00007298166,0.002688503],"genre_scores_gemma":[0.9835053,0.004948537,0.0003168547,0.00809045,0.0003233945,0.00007374319,0.0001805149,0.0002484709,0.002312719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04766024,"threshold_uncertainty_score":0.9999251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715183600050761,"score_gpt":0.2964374050564805,"score_spread":0.2792855690559729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}