{"id":"W2963978412","doi":"10.1016/j.omto.2019.07.003","title":"Coxsackievirus Type B3 Is a Potent Oncolytic Virus against KRAS-Mutant Lung Adenocarcinoma","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; St. Paul's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC; Terry Fox Research Institute; University of British Columbia; Canadian Lung Association; BC Cancer Foundation; Vancouver Coastal Health Research Institute; British Columbia Lung Association; Canadian Institutes of Health Research; Mitacs; International Association for the Study of Lung Cancer","keywords":"Oncolytic virus; KRAS; Virology; Adenocarcinoma; Coxsackievirus; Mutant; Cancer research; Virus; Biology; Mutation; Medicine; Enterovirus; Internal medicine; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002219226,0.0002417854,0.0001665471,0.0002651117,0.0002180318,0.000284958,0.0001588151,0.0003152583,0.001068158],"category_scores_gemma":[0.0001430559,0.0001159069,0.0002032744,0.0002755745,0.0002512965,0.0001854367,0.0001680463,0.0007959347,0.0004026539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003952906,"about_ca_system_score_gemma":0.0004778821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002618941,"about_ca_topic_score_gemma":0.002891339,"domain_scores_codex":[0.9999061,0.00002082456,0.000005675705,0.00001141125,0.00003102599,0.00002499343],"domain_scores_gemma":[0.9999223,0.00001642949,0.00001590801,0.000008104951,0.000009931947,0.00002744915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003249157,0.00006588593,0.0002795529,0.00006687467,0.000009389438,0.00005911267,0.00001588537,0.000117345,0.9927421,0.0005833542,0.0004300389,0.005305569],"study_design_scores_gemma":[0.000182039,0.002157894,0.006355524,0.00002191413,0.00003218438,0.001124761,0.00004048643,0.001331489,0.9619945,0.0003101768,0.02643617,0.00001288808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9628847,0.01282238,0.01149175,0.0008729569,0.0003167923,0.0002547122,0.001368113,0.0002908217,0.009697727],"genre_scores_gemma":[0.9835306,0.004583496,0.005487023,0.000121287,0.00002897664,0.00006853614,0.001497998,0.00003883049,0.004643322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002618941,"threshold_uncertainty_score":0.005207419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715183600050761,"score_gpt":0.2964374050564805,"score_spread":0.2792855690559729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}