{"id":"W2964013225","doi":"10.1007/s13311-019-00765-w","title":"The Novel Small Molecule TRVA242 Stabilizes Neuromuscular Junction Defects in Multiple Animal Models of Amyotrophic Lateral Sclerosis","year":2019,"lang":"en","type":"article","venue":"Neurotherapeutics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Treventis (Canada); Montreal Neurological Institute and Hospital; University of Toronto; Fonds de Recherche du Québec - Santé; St. Michael's Hospital; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Mitacs; ALS Society of Canada","keywords":"Amyotrophic lateral sclerosis; Zebrafish; SOD1; Neuroscience; C9orf72; Neuromuscular junction; Biology; Caenorhabditis elegans; Neurology; Medicine; Trinucleotide repeat expansion; Genetics; Disease; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002432178,0.0005657206,0.0006456563,0.0005081929,0.0003475108,0.0004958152,0.0006776293,0.000663723,0.002051933],"category_scores_gemma":[0.0001749464,0.0001922497,0.0003821826,0.0002478789,0.0003848119,0.0003915523,0.0002103254,0.00113361,0.0006662824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003731807,"about_ca_system_score_gemma":0.0003030058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000530022,"about_ca_topic_score_gemma":0.000936311,"domain_scores_codex":[0.9998164,0.00002728147,0.0000145809,0.00003799346,0.00005268882,0.00005116457],"domain_scores_gemma":[0.9999068,0.00001239339,0.00002481643,0.00001171576,0.00001131774,0.00003298537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000389585,0.00008350321,0.00005661874,0.00004763903,0.00002676587,0.00007656703,0.00001060681,0.0001349154,0.9961275,0.0001427341,0.0001621862,0.002741418],"study_design_scores_gemma":[0.00020755,0.001316155,0.001025033,0.000009603505,0.00004983547,0.000355583,0.00002555455,0.0006141826,0.9928603,0.00009245722,0.003429994,0.00001371824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923684,0.002544607,0.001884274,0.0002653042,0.0001407002,0.00004085262,0.0004158805,0.0003178157,0.002022366],"genre_scores_gemma":[0.9935267,0.001341976,0.001322854,0.00005536039,0.00003495838,0.00005724172,0.0006029906,0.00004218748,0.00301581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002051933,"threshold_uncertainty_score":0.006864369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08397349794007626,"score_gpt":0.2682037699739577,"score_spread":0.1842302720338815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}