{"id":"W2964013225","doi":"10.1007/s13311-019-00765-w","title":"The Novel Small Molecule TRVA242 Stabilizes Neuromuscular Junction Defects in Multiple Animal Models of Amyotrophic Lateral Sclerosis","year":2019,"lang":"en","type":"article","venue":"Neurotherapeutics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Treventis (Canada); Montreal Neurological Institute and Hospital; University of Toronto; Fonds de Recherche du Québec - Santé; St. Michael's Hospital; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Mitacs; ALS Society of Canada","keywords":"Amyotrophic lateral sclerosis; Zebrafish; SOD1; Neuroscience; C9orf72; Neuromuscular junction; Biology; Caenorhabditis elegans; Neurology; Medicine; Trinucleotide repeat expansion; Genetics; Disease; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002975749,0.0002762382,0.0004294453,0.000159173,0.00009777248,0.00005139163,0.0002887866,0.0001627133,0.00004267934],"category_scores_gemma":[0.0000705542,0.0001982037,0.0002113895,0.0004928785,0.000185058,0.0001337594,0.00009029296,0.0005601374,0.00002823661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001001338,"about_ca_system_score_gemma":0.0001101445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002141603,"about_ca_topic_score_gemma":0.00008613555,"domain_scores_codex":[0.9975718,0.0002002895,0.0005140142,0.0004857663,0.0006304041,0.0005976999],"domain_scores_gemma":[0.9985776,0.0002572198,0.0001290417,0.0007218885,0.0001838742,0.0001303804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001116457,0.0003464364,0.04311433,0.00009819664,0.00005125302,0.000008125927,0.0001919211,0.002057805,0.9515526,0.0002496132,0.000005747419,0.001207456],"study_design_scores_gemma":[0.006307088,0.002228876,0.8085797,0.000163753,0.0000711114,0.00002069474,0.00004372103,0.1434136,0.038123,0.0001568555,0.0005973154,0.0002943132],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969791,0.0002301238,0.000213127,0.0007453457,0.0001728767,0.001343624,0.000007479412,0.00005891941,0.0002494711],"genre_scores_gemma":[0.998249,0.0004712483,0.0002363272,0.0006623876,0.00005373274,0.00005366748,0.000005808914,0.00009446612,0.0001733814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9134297,"threshold_uncertainty_score":0.8082514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08397349794007626,"score_gpt":0.2682037699739577,"score_spread":0.1842302720338815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}