{"id":"W2964054295","doi":"10.1074/jbc.ra119.009584","title":"Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Canada Foundation for Innovation; Government of Canada; Vancouver Coastal Health Research Institute; Canada Research Chairs","keywords":"Proinflammatory cytokine; Biology; Cell biology; Chemokine; Inflammation; Biochemistry; Receptor; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002266456,0.0003764255,0.0002777168,0.0001344395,0.00007819778,0.0002480238,0.0001225348,0.0002009716,0.001185728],"category_scores_gemma":[0.0002005675,0.0001225744,0.000427843,0.00007167814,0.0001679969,0.000150366,0.0001412838,0.0005324046,0.0003037115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001334736,"about_ca_system_score_gemma":0.000175399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001865282,"about_ca_topic_score_gemma":0.0003346657,"domain_scores_codex":[0.9998048,0.00004193726,0.00002350462,0.00002158924,0.00004450862,0.00006381673],"domain_scores_gemma":[0.9998651,0.00002387991,0.00004364293,0.00002029908,0.00001765329,0.00002949952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001260343,0.0000266172,0.0001067584,0.0000340456,0.000006844061,0.00006826523,0.000007460789,0.00001433553,0.9986141,0.00003343821,0.00004111115,0.0009210254],"study_design_scores_gemma":[0.00007443144,0.0007515244,0.004013571,0.000009397711,0.00002171077,0.0006004134,0.00002841367,0.0006469099,0.990764,0.00005778583,0.00302774,0.00000419873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909499,0.004528234,0.002993638,0.000187889,0.0001039569,0.00004476705,0.0002212577,0.0001033431,0.00086692],"genre_scores_gemma":[0.995589,0.001210225,0.001429604,0.00006233028,0.00002500828,0.00002708386,0.0003242894,0.00001106896,0.001321315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001185728,"threshold_uncertainty_score":0.00396663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01187353335749585,"score_gpt":0.2350569479746274,"score_spread":0.2231834146171316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}