{"id":"W2964054673","doi":"10.1016/j.jsb.2019.07.009","title":"Cryo-electron microscopy structures of ArnA, a key enzyme for polymyxin resistance, revealed unexpected oligomerizations and domain movements","year":2019,"lang":"en","type":"article","venue":"Journal of Structural Biology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Japan Society for the Promotion of Science; Canadian Institutes of Health Research","keywords":"Random hexamer; Lipid A; Chemistry; Biophysics; Bacteria; Crystallography; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008802657,0.000195757,0.0001078583,0.0001340945,0.000367359,0.0003066758,0.0001809546,0.0003007113,0.0008017845],"category_scores_gemma":[0.0001553511,0.0001902805,0.0001955604,0.00007909843,0.0003279771,0.0004145952,0.0002018355,0.001135798,0.000283508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003104915,"about_ca_system_score_gemma":0.000134592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007002499,"about_ca_topic_score_gemma":0.0009636524,"domain_scores_codex":[0.999974,0.000002792744,0.0000014287,0.000007884148,0.000006015111,0.000007945673],"domain_scores_gemma":[0.9998795,0.00003822611,0.00002257865,0.00001783357,0.00001691106,0.00002498656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001384285,0.00003310547,0.001151051,0.00004434884,0.0000164756,0.0004030634,0.00009238737,0.001038912,0.9945239,0.0009458459,0.000283234,0.001329301],"study_design_scores_gemma":[0.0000332267,0.00009744455,0.03360201,0.00003659094,0.00005898266,0.001891933,0.0003256178,0.03258236,0.9235374,0.001185092,0.006621204,0.00002812415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909334,0.0005788009,0.006192586,0.0002977741,0.00002425137,0.000007453541,0.0002063489,0.00006456333,0.00169486],"genre_scores_gemma":[0.9952108,0.0002863506,0.00309795,0.0000663775,0.000005192047,0.000006950615,0.0002849525,0.00003067042,0.001010831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008017845,"threshold_uncertainty_score":0.002682209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004347007368008385,"score_gpt":0.2712060111311812,"score_spread":0.2668590037631728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}