{"id":"W2964093992","doi":"10.1523/eneuro.0035-19.2019","title":"GPR88 in D1R-Type and D2R-Type Medium Spiny Neurons Differentially Regulates Affective and Motor Behavior","year":2019,"lang":"en","type":"article","venue":"eNeuro","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; Walloon excellence in life sciences and biotechnology; National Institute on Drug Abuse; Conseil Régional d'Alsace; Fonds Unique Interministériel; Canada Research Chairs; Canada Foundation for Innovation; Fondation pour la Recherche Médicale; Fonds De La Recherche Scientifique - FNRS","keywords":"Medium spiny neuron; Striatum; Nucleus accumbens; Open field; Neuroscience; Motor coordination; Pharmacology; Psychology; Biology; Endocrinology; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009995547,0.0002518244,0.0002973254,0.0002119351,0.0001260815,0.0002747159,0.0001927438,0.0003156487,0.001178027],"category_scores_gemma":[0.0001182399,0.0001721855,0.0003308349,0.00008784251,0.0003291053,0.0002355478,0.0002715284,0.0006497722,0.0002546325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002705885,"about_ca_system_score_gemma":0.0001633257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000613877,"about_ca_topic_score_gemma":0.001223456,"domain_scores_codex":[0.9998023,0.00001703902,0.00001629533,0.00005861513,0.00003412195,0.0000716096],"domain_scores_gemma":[0.9999021,0.00000512945,0.00003477523,0.000008073313,0.000006704678,0.00004313171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004228965,0.00002399694,0.001043418,0.00001932293,0.000005609848,0.00006040193,0.00001854449,0.0000256102,0.9972243,0.00007194019,0.00002944193,0.001054594],"study_design_scores_gemma":[0.0002165525,0.001679837,0.2670279,0.00003273398,0.0001342296,0.00188119,0.0004787681,0.001753835,0.7234908,0.0002843325,0.0029858,0.00003398168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987833,0.0002246364,0.0004008608,0.00004614722,0.000009041975,0.000004380603,0.0001628201,0.00001009069,0.0003587322],"genre_scores_gemma":[0.9970199,0.0003372784,0.000614898,0.00006083974,0.00000631313,0.00002061587,0.0002685061,0.000009149503,0.001662421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001178027,"threshold_uncertainty_score":0.00394088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006368443027636973,"score_gpt":0.2249313284240109,"score_spread":0.2185628853963739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}