{"id":"W2964117905","doi":"10.1038/s41422-019-0203-2","title":"Forkhead domain mutations in FOXA1 drive prostate cancer progression","year":2019,"lang":"en","type":"letter","venue":"Cell Research","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"CIHR Skin Research Training Centre; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of California, San Francisco; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; U.S. Department of Health and Human Services; National Institutes of Health; Terry Fox Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Prostate Cancer Canada; U.S. Department of Defense; Princess Margaret Cancer Foundation; Massachusetts General Hospital; Government of Canada","keywords":"Biology; FOXA1; Prostate cancer; Forkhead Transcription Factors; Cancer research; Domain (mathematical analysis); Genetics; Mutation; Cancer; Computational biology; Bioinformatics; Gene; Regulation of gene expression; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008165431,0.0005681501,0.0007191522,0.0004109653,0.001245859,0.00115982,0.0005853148,0.009024483,0.004524218],"category_scores_gemma":[0.003353487,0.0004820422,0.0006371827,0.0002603822,0.001484072,0.0007485318,0.0004715828,0.007428566,0.001466121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001692854,"about_ca_system_score_gemma":0.0006573072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002507536,"about_ca_topic_score_gemma":0.003830169,"domain_scores_codex":[0.9995747,0.0001012867,0.00003851579,0.00007141825,0.0001135316,0.0001005453],"domain_scores_gemma":[0.9988791,0.0006930398,0.00009013239,0.00006546823,0.0001008957,0.0001713269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.002221593,0.0003180593,0.00670407,0.000285143,0.0002079925,0.10517,0.0004963899,0.0007822521,0.04175023,0.02974987,0.7665853,0.04572911],"study_design_scores_gemma":[0.001387371,0.0006381148,0.0140928,0.0002088853,0.0002768956,0.05871825,0.0006015123,0.005961769,0.02901578,0.039886,0.8490006,0.000212114],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.03572631,0.005785266,0.001653966,0.8920711,0.0397102,0.00007126426,0.0005888921,0.0003590289,0.02403391],"genre_scores_gemma":[0.3653889,0.009240508,0.002352568,0.4684281,0.07366593,0.0001833151,0.0003294676,0.0002438494,0.08016735],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009024483,"threshold_uncertainty_score":0.01513505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04058483965355127,"score_gpt":0.3782005451824062,"score_spread":0.3376157055288549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}