{"id":"W2964117905","doi":"10.1038/s41422-019-0203-2","title":"Forkhead domain mutations in FOXA1 drive prostate cancer progression","year":2019,"lang":"en","type":"letter","venue":"Cell Research","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"CIHR Skin Research Training Centre; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of California, San Francisco; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; U.S. Department of Health and Human Services; National Institutes of Health; Terry Fox Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Prostate Cancer Canada; U.S. Department of Defense; Princess Margaret Cancer Foundation; Massachusetts General Hospital; Government of Canada","keywords":"Biology; FOXA1; Prostate cancer; Forkhead Transcription Factors; Cancer research; Domain (mathematical analysis); Genetics; Mutation; Cancer; Computational biology; Bioinformatics; Gene; Regulation of gene expression; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005042882,0.0002260569,0.0002007891,0.0003318762,0.0001039675,0.00006985836,0.0003302558,0.0008685801,0.0001048884],"category_scores_gemma":[0.00003025977,0.0002142593,0.0001010279,0.0002983193,0.0002006871,0.00000735711,0.0001090704,0.001390497,0.0001256456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001536232,"about_ca_system_score_gemma":0.0004443199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007909807,"about_ca_topic_score_gemma":0.0001325654,"domain_scores_codex":[0.9972804,0.0004042571,0.0002788354,0.0006853202,0.000685218,0.0006659791],"domain_scores_gemma":[0.9989613,0.00005168507,0.00008412406,0.0005298887,0.0003205809,0.00005239317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009142104,0.00005637535,0.001782382,0.0003781845,0.00002114365,0.00004127669,0.0002726589,0.00006484698,0.2976918,0.000006928786,0.696987,0.002605936],"study_design_scores_gemma":[0.0007327021,0.0002198666,0.0009964037,0.000159122,0.000006106457,0.00000193757,0.0000598415,0.00004088267,0.05536553,0.000270562,0.9418892,0.000257841],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5477545,0.006916479,0.0002449131,0.41782,0.001299095,0.00749074,0.0005861449,0.00006128256,0.01782686],"genre_scores_gemma":[0.7571847,0.00199457,0.001921489,0.06984176,0.005881638,0.003769261,0.02539136,0.0005624672,0.1334528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3479783,"threshold_uncertainty_score":0.8737242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04058483965355127,"score_gpt":0.3782005451824062,"score_spread":0.3376157055288549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}