{"id":"W2964166353","doi":"10.1182/bloodadvances.2018028423","title":"Distinct clinical and biological implications of CUX1 in myeloid neoplasms","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Edward P. Evans Foundation","keywords":"Frameshift mutation; Myeloid; Cancer research; Biology; Myeloid leukemia; Somatic cell; Gene knockdown; Progenitor cell; Locus (genetics); Germline; Bone marrow; Myelodysplastic syndromes; Genetics; Germline mutation; Gene; Molecular biology; Mutation; Immunology; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003493137,0.0001924628,0.0002030324,0.0007265568,0.0003060335,0.0003064563,0.0002087079,0.0002647213,0.001293902],"category_scores_gemma":[0.001114386,0.00009805751,0.0001004106,0.0003017149,0.0004224562,0.0001880488,0.0003824851,0.0002023568,0.0001786942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002228779,"about_ca_system_score_gemma":0.0001424441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000295028,"about_ca_topic_score_gemma":0.0003882913,"domain_scores_codex":[0.9997243,0.00005731086,0.00002633336,0.000073535,0.00006035917,0.00005814213],"domain_scores_gemma":[0.9993588,0.0001600468,0.0001884766,0.00004702218,0.00007428289,0.0001712445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001584654,0.0001039236,0.914018,0.00005346673,0.00003909375,0.005923395,0.0002272402,0.0001715792,0.06084297,0.0004006168,0.0002183302,0.01641666],"study_design_scores_gemma":[0.00002527702,0.0004496599,0.9691431,0.00001225978,0.00003285107,0.02341306,0.0002088987,0.0002723415,0.005018429,0.0003043455,0.001113532,0.000006334201],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989595,0.0004335397,0.0000753617,0.00001883378,0.000002580625,0.000004587012,0.00005721614,0.000003148572,0.0004451224],"genre_scores_gemma":[0.9996603,0.00007535143,0.00005564116,0.000007586826,0.000005589956,0.000002698778,0.00009573966,0.000001459876,0.00009565231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001293902,"threshold_uncertainty_score":0.004328489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03496682625663507,"score_gpt":0.3643098961475505,"score_spread":0.3293430698909154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}