{"id":"W2964236653","doi":"10.1128/iai.00227-19","title":"Intradermal Synthetic DNA Vaccination Generates <i>Leishmania</i> -Specific T Cells in the Skin and Protection against Leishmania major","year":2019,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; W. W. Smith Charitable Trust","keywords":"Vaccination; Smallpox; Biology; DNA vaccination; Virology; Leishmania; Immunology; Leishmania major; Leishmaniasis; Smallpox vaccine; Immune system; Immunization; Vaccinia; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002296801,0.0002010091,0.0001539512,0.0001990474,0.00007628914,0.0002544493,0.0001520007,0.0003522387,0.002432255],"category_scores_gemma":[0.0001675132,0.0001061237,0.000163227,0.0001141801,0.0003348696,0.0002430247,0.0001252791,0.000776026,0.0007160874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002164559,"about_ca_system_score_gemma":0.0002058262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001629645,"about_ca_topic_score_gemma":0.0002469127,"domain_scores_codex":[0.999881,0.00003006496,0.000007641267,0.00003007147,0.00002666536,0.00002453849],"domain_scores_gemma":[0.9999303,0.00001504552,0.00002201559,0.000008086772,0.000009274546,0.00001519138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001930367,0.0001169719,0.0001806576,0.0001296625,0.000005266436,0.00003573116,0.00002496793,0.0001139543,0.9932093,0.0004466009,0.0001923362,0.005351609],"study_design_scores_gemma":[0.0001143899,0.003746948,0.002190651,0.00004389522,0.00003598924,0.000492034,0.00007210582,0.0006531334,0.980327,0.0002934317,0.0120226,0.000007808869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704431,0.006150926,0.01395844,0.001037586,0.0003891538,0.0002379006,0.0006596992,0.0002265751,0.006896595],"genre_scores_gemma":[0.9891104,0.001994506,0.004270691,0.0002266105,0.00004809733,0.00004817611,0.0004566188,0.00001809582,0.00382681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002432255,"threshold_uncertainty_score":0.00813669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02025223914365057,"score_gpt":0.2549049622287053,"score_spread":0.2346527230850548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}